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输卵管作为精卵结合的必经之路，其微环境对精子在输卵管中的定向运动及后期的成功受精极为关键。临床发现，并非精力充沛、运动速度快的精子能够在众多竞争中胜出，而是埋伏在输卵管壁面绒毛内的精子，等待合适的时机才能迁移到卵子附近完成受精。然而，对精子与输卵管上皮细胞表面的相互作用，以及从静态到苏醒并迁移的过程，现有的实验方法和理论研究仍颇受挑战。
顾宏周课题组与合作者《Nature Chemistry》报道利用DNA纳米组装体按尺寸精确分选脂质体新策略用于曲率依赖的膜相关反应研究（图）
粒径 曲率 DNA 纳米 囊泡 物医学研究院
2023/4/17
在细胞中，无论是胞内囊泡与细胞器还是胞外的分泌囊泡，大量膜蛋白可以在具有极高曲率的弯曲膜上 (曲率半径<50 nm）分布并维持其结构域，为了理解这些膜蛋白与高曲率膜的依存关系及其功能行为，人们亟需一种模型体系进行膜结构的仿生研究，而粒径大小精确可控的脂质体可以提供这样的理想平台（粒径与曲率成反比）。在现有的脂质体制备策略中，粒径大小的调控依赖于制备条件、均一化的处理方式及纯化方式等，但得到的脂质体...
阿尔兹海默症（Alzheimer disease，AD）是一种神经系统退行性疾病，以记忆障碍、失语、失用、失认、视空间技能损害等为主要症状。据世界卫生组织统计，截止2018年底，全球痴呆人数已经超过5000万人，其中AD患者约占70%，AD已成为影响全球的重大公共健康问题。
Geology and Mineral Chemistry of Gold Mineralization in Mirge-Naqshineh Occurrence (Saqez, NW Iran): Implications for Transportation and Precipitation of Gold
gold quartz veins mineral chemistry EPMA Mirge-Naqshineh Iran
2018/4/10
The Mirge-Naqshineh gold district is situated at northwest of Iran with a NW-trending brittle-ductile shear zone. It is hosted by Precambrian meta-sedimentary and meta-volcanic units traversed by mine...
Preface: Evolution of the solar system: New advances in cosmochemistry and planetary chemistry
cosmochemistry planetary chemistry
2017/4/10
The understanding of evolution of solar system has been
recently entered a phase of major change with the results
of new astronomical observation, several primitive extraterrestrial
samples includi...
Stark Spectroscopy:Applications in Chemistry,Biology and Materials Science
electroabsorption electrochromism electro-optic absorption electric field charge transfer
2016/5/23
Stark spectroscopy has been applied to a wide range of molecular systems and materials. A generally useful method for obtaining electronic and vibrational Stark spectra that does not require sophistic...
From Transistor to Trapped-ion Computers for Quantum Chemistry
Transistor Trapped-ion Computers Quantum Chemistry
2016/1/22
Over the last few decades, quantum chemistry has progressed through the development of computational methods based on modern digital computers. However, these methods can hardly fulfill the exponentia...
Introduction to Quantum Algorithms for Physics and Chemistry
Introduction Quantum Algorithms Physics Chemistry
2016/1/22
Controllable quantum systems provide unique opportunities for solving problems in quantum chemistry and many-body physics that are intractable by classical computers. This approach is called “quantum ...
Radon, water chemistry and pollution check by volatile organic compounds in springs around Popocatepetl volcano, Mexic
soil radon water chemistry volcanic activity
2015/9/10
Popocatepetl volcano is a high-risk active volcano in Central Mexico where the highest population density in the country
is settled. Radon in the soil and groundwater together with water chemistry fr...
A new chemistry option in WRF-Chem v. 3.4 for the simulation of direct and indirect aerosol effects using VBS:evaluation against IMPACT-EUCAARI data
WRF-Chem v. 3.4 direct and indirect aerosol VBS IMPACT-EUCAARI data
2015/9/10
A parameterization for secondary organic aerosol (SOA) production based on the volatility basis set (VBS) approach has been coupled with microphysics and radiative schemes in the Weather Research and ...
Water chemistry and soil radon survey at the Poas volcano (Costa Rica)
Poas volcano geochemistry radon precursor
2015/9/10
Radon-in-soil monitoring at the Poas volcano (Costa Rica) has been performed together with water chemistry
from the hot crater lake since 1981 and 1983 respectively. The results are discussed as a fu...
Studies on Major Ion Chemistry and Hydrogeochemical Processes of Groundwater in Port Harcourt City, Southern Nigeria
Groundwater Port Harcourt City Nigeria
2015/8/14
Of recent, the rapid deterioration of groundwater quality in Port Harcourt, Southern Nigeria due to unregulated exploitation resulting from increasing growth in the oil and gas production activities h...
Accounting for instream lakes when interpolating stream water chemistry observations
geostatistics kriging stream water chemistry
2015/8/14
Direct monitoring of stream water chemistry is an increasingly important tool for securing stream water quality and assessing stream ecological functioning as it relates to overall ecosystem health. S...
New Sensor Technology for In Situ Measurements of Ocean Chemistry
New Sensor Technology Situ Measurements Ocean Chemistry
2015/8/14
Chemical processes in the ocean and at its interfaces with the atmosphere and the seafloor play a major role in regulating global biogeochemical cycles. Predicting the impact of human disturbances on ...
Revision of the convective transport module CVTRANS 2.4 in the EMAC atmospheric chemistry–climate model
EMAC atmospheric chemistry–climate model convective transport
2015/8/11
The convective transport module, CVTRANS,
of the ECHAM/MESSy Atmospheric Chemistry (EMAC)
model has been revised to better represent the physical flows
and incorporate recent findings o...