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近日，北京大学第三医院心血管内科徐明教授团队在代谢顶级期刊 《自然·代谢》 （Nature Metabolism）在线发表了题为《TGR5抑制脂肪酸摄取改善糖尿病心肌病》（Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy）的研究成果，揭示了糖尿病心肌病心脏脂代谢调节新机制，架起了胆汁酸代谢与心脏脂代谢之...
Kalancho? PPC1 is Essential for Crassulacean Acid Metabolism and the Regulation of Core Circadian Clock and Guard Cell Signaling Genes
Crassulacean acid metabolism (CAM) plants oxaloacetate phosphoenolpyruvate carboxylase circadian clock
2024/1/22
Unlike C3 plants, Crassulacean acid metabolism (CAM) plants fix CO2 in the dark using phosphoenolpyruvate carboxylase (PPC; EC 4.1.1.31). PPC combines PEP with CO2 (as HCO3-), forming oxaloacetate tha...
PI4Kγ2 interacts with E3 ligase MIEL1 to regulate auxin metabolism and root development
phosphatidylinositol 4-kinase γ2 (PI4Kγ2) MIEL1 MYB30 auxin GH3
2023/12/21
Root development is important for normal plant growth and nutrient absorption. Studies have revealed the involvement of various factors in this complex process, improving our understanding of the rele...
ERF Gene Clusters: Working Together to Regulate Metabolism
ERF transcription factorgene clusterjasmonates specialized metabolism
2023/12/18
Plants produce structurally diverse specialized metabolites, including bioactive alkaloids and terpenoids, in response to biotic and abiotic environmental stresses. The APETALA2/ETHYLENE RESPONSE FACT...
Primary carbohydrate metabolism genes participate in heat-stress memory at the shoot apical meristem of Arabidopsis thaliana
aldolase carbon metabolism heat stress shoot apical meristem thermomemory thermopriming
2023/12/5
In plants, the shoot apical meristem (SAM) is essential for the growth of aboveground organs. However, little is known about its molecular responses to abiotic stresses. Here, we show that the SAM of ...
Single-cell transcriptomics sheds light on the identity and metabolism of developing leaf cells
Single-cell transcriptomics photosynthetic Arabidopsis thaliana high-throughput transcriptome metabolic stress-related
2023/11/30
As the main photosynthetic instruments of vascular plants, leaves are crucial and complex plant organs. A strict organization of leaf mesophyll and epidermal cell layers orchestrates photosynthesis an...
线粒体是细胞中重要的能量供应场所和代谢中心，主要通过氧化磷酸化过程合成ATP为细胞提供能量。线粒体同时也参与调控先天性免疫及细胞程序性死亡等生理过程。线粒体功能损伤会影响细胞甚至机体的正常生命活动，诱发一系列严重疾病例如神经功能障碍，慢性病，心力衰竭等，因此保障线粒体正常运作（内环境稳态）具有重要意义。而线粒体未折叠蛋白质反应（mitochondrial unfolded protein resp...
肥胖是肿瘤、糖尿病和心血管等重大疾病的重要危险因素之一，纠正肥胖代谢失衡有助于民众健康，具有重要的社会经济效益。支链氨基酸（BCAA）代谢与肥胖密切相关，体内BCAA及其代谢物的增加与肥胖相关代谢疾病呈正相关，高BCAA饮食可加重肥胖，低BCAA饮食能改善肥胖。肥胖的特征之一是白色脂肪的增加，然而BCAA代谢在白色脂肪的作用以及促进肥胖的机制一直不清楚。
足够的营养是细胞增殖和组织发育的必要条件。细胞增殖和组织发育需要上调组蛋白乙酰化来激活基因转录。二者之间的联系，也就是：“营养物信号如何被传递到组蛋白乙酰化？”这个基础生物医学问题，长期未能得到阐明。
线粒体是细胞内一类非常重要的细胞器，具有独立于细胞核的遗传物质（mtDNA）及相应的基因转录和蛋白翻译系统。与此同时，线粒体也是细胞代谢的重要区室，因其在能量代谢中的重要作用被称为“细胞的能量工厂”。线粒体代谢和生物合成异常在肿瘤、心血管疾病、神经退行性疾病、衰老等疾病的进程中具有关键的调控作用。线粒体量在细胞内被动态调节，并与细胞的代谢状态密切相关。目前对细胞如何感知营养状态调控核编码线粒体基因...
Metabolites and Transcriptional Profiling Analysis Reveal the Molecular Mechanisms of the Anthocyanin Metabolism in the “Zijuan” Tea Plant (Camellia sinensis var. assamica)
Camellia sinensis L. transcriptome anthocyanin biosynthesis metabolism degradation
2023/4/20
Anthocyanins are natural colorants that have attracted increasing attention because of their extensive range of antioxidant, antimutagenic, and health-promoting properties. The mechanism of anthocyani...
Transporters and ascorbate–glutathione metabolism for differential cadmium accumulation and tolerance in two contrasting willow genotypes
Transporters ascorbate–glutathione metabolism cadmium accumulation willow
2023/6/5
Salix matsudanais a low cadmium (Cd)-accumulating willow (LCW), whereas its cultivated variety, Salix matsudana var. matsudana f. umbraculifera Rehd., is a high Cd-accumulating and tolerant willow (HC...
Quantitative proteomic analysis of Malus halliana exposed to salt-alkali mixed stress reveals alterations in energy metabolism and stress regulation
Apple rootstock.Malus halliana.Salt-alkali.iTRAQ. Energy metabolism Protein–protein interaction
2024/2/4
Soil salinization is a major abiotic stress in apple production; consequently, it is important to improve the salt tolerance of apple trees. Here, a physiological analysis and isobaric tags for relati...
COMBINING URBAN METABOLISM METHODS AND SEMANTIC 3D CITY MODELS
Stocks and Flows, Urban Metabolism 3D City Model CityGML General Indicator Model GIM Dynamizer
2018/11/9
he last decade has witnessed increasing interest in the study of urban stocks and flows. This paper provides a literature review for different studies of urban stocks and flows. The review shows that ...
Gender and Age Effects on the Expression of Genes Related to Lipid Metabolism in Broiler’s Liver
apolipoprotein lipogenesis lipolysis
2018/3/5
Two experiments were conducted to assess gender (Experiment 1) and age (Experiment 2) effects on the
expression of genes related to lipid metabolism in broiler chickens. The expression of fatty acid ...
