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慢性胰腺炎是一种进行性纤维化炎症疾病,其特点是炎症的反复发作和广泛的胰腺组织纤维化。慢性胰腺炎发病率逐年升高,但其发病机制尚未完全阐明。探究胰腺炎组织纤维化的诱发机制可以为胰腺炎疾病的预防和治疗开辟新的潜在策略。近日,上海中医药大学附属龙华医院杨旭光与复旦大学上海医学院的林玉丽团队展开合作研究,从基质细胞代谢过程调节免疫微环境这一新视角出发,深度剖析了慢性胰腺炎组织纤维化的诱发机制,在国际顶级免疫...
B淋巴细胞在肿瘤免疫中的研究是新近热点。在实体肿瘤中发现B细胞浸润及其构成的三级淋巴结构(Tumor-associated tertiary lymphoid structures,TLS)与抗肿瘤免疫激活、免疫治疗响应密切相关[1-3]。但是, B细胞也通过肿瘤免疫微环境与免疫调节发挥促肿瘤免疫抑制效应[4-6],后者的研究存在较多空白[7, 8]。因此,剖析肿瘤浸润B细胞的特性及其调节功能的获...
近日,中国疾病预防控制中心病毒病预防控制所刘军研究员团队与深圳华大生命科学研究院、解放军总医院第五医学中心、北京地坛医院和深圳国家基因库等机构科学家联合在Cell子刊Immunity杂志(IF:22.5)上在线发表题为“Single-cell sequencing of peripheral blood mononuclear cells reveals distinct immune respo...
The aging process can lead to a decline in cellular immunity. Therefore, the elderly could benefit from safe and effective interventions that restore cellular immune functions.
Probiotics: effects on immunity     inflammation  probiotics  antigen       2016/6/12
The gastrointestinal tract functions as a barrier against antigens from microorganisms and food. The generation of immunophysiologic regulation in the gut depends on the establishment of indigenous...
Epidemiologic observations have linked an increased risk of colorectal cancer (CRC)3 and inflammatory bowel disease with distance from the equator (1–3). Notably, inflammatory bowel disease is a risk ...
Purpose: To examine the effects of intensity and duration of exercise stress on induction of in vivo immunity in humans using experimental contact hypersensitivity (CHS) with the novel antigen dipheny...
Cervical cancer was shown by Professor Harald zur Hausen in the early 1980s to be initiated by infection of cervical epithelium with certain human papillomaviruses, now designated as “high risk” papil...
There has been an increase in the preventable communicable disease known as Pertussis as the result of waning immunity in adolescents and adults. Waning immunity is the loss of protective antibodies o...
Background: Rubella is a viral disease with a worldwide distribution. Mass vaccination campaigns have increased the vaccine coverage in the world with substantial impact on reduction of rubella infect...
Background: Rubella is a viral disease with a worldwide distribution. Mass vaccination campaigns have increased the vaccine coverage in the world with substantial impact on reduction of rubella infect...
Immunotherapy for cancer has held much promise as a potent modality of cancer treatment. The ability to selectively destroy diseased cells and leave healthy cells unharmed has been the goal of cancer ...
To determine the immunity of health care workers (HCWs) against measles, rubella, mumps, and varicella infections, and to evaluate the reliability of self-reported history of the disease in predicting...
To determine the immunity of health care workers (HCWs) against measles, rubella, mumps, and varicella infections, and to evaluate the reliability of self-reported history of the disease in predicting...
Urticarial rash, one of the clinical manifestations characteristic of cryopyrin-associated periodic syndrome (CAPS), is caused by a mutation in the gene encoding for NLRP3 (nucleotide-binding oligomer...

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