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慢性胰腺炎是一种进行性纤维化炎症疾病，其特点是炎症的反复发作和广泛的胰腺组织纤维化。慢性胰腺炎发病率逐年升高，但其发病机制尚未完全阐明。探究胰腺炎组织纤维化的诱发机制可以为胰腺炎疾病的预防和治疗开辟新的潜在策略。近日，上海中医药大学附属龙华医院杨旭光与复旦大学上海医学院的林玉丽团队展开合作研究，从基质细胞代谢过程调节免疫微环境这一新视角出发，深度剖析了慢性胰腺炎组织纤维化的诱发机制，在国际顶级免疫...
B淋巴细胞在肿瘤免疫中的研究是新近热点。在实体肿瘤中发现B细胞浸润及其构成的三级淋巴结构（Tumor-associated tertiary lymphoid structures，TLS）与抗肿瘤免疫激活、免疫治疗响应密切相关[1-3]。但是， B细胞也通过肿瘤免疫微环境与免疫调节发挥促肿瘤免疫抑制效应[4-6]，后者的研究存在较多空白[7, 8]。因此，剖析肿瘤浸润B细胞的特性及其调节功能的获...
近日，中国疾病预防控制中心病毒病预防控制所刘军研究员团队与深圳华大生命科学研究院、解放军总医院第五医学中心、北京地坛医院和深圳国家基因库等机构科学家联合在Cell子刊Immunity杂志（IF：22.5）上在线发表题为“Single-cell sequencing of peripheral blood mononuclear cells reveals distinct immune respo...
Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019
Probiotics elderly immunosenescence
2016/6/14
The aging process can lead to a decline in cellular
immunity. Therefore, the elderly could benefit from safe and
effective interventions that restore cellular immune functions.
The gastrointestinal tract functions as a barrier
against antigens from microorganisms and food. The generation
of immunophysiologic regulation in the gut depends on
the establishment of indigenous...
Epidemiologic observations have linked an increased risk of colorectal cancer (CRC)3 and inflammatory bowel disease with distance from the equator (1–3). Notably, inflammatory bowel disease is a risk ...
Exercise Intensity and Duration Effects on In Vivo Immunity
STRESS RUNNING IMMUNE CONTACT HYPERSENSITIVITY DIPHENCYPRONE IRRITANT
2017/4/19
Purpose: To examine the effects of intensity and duration of exercise stress on induction of in vivo immunity in humans using experimental contact hypersensitivity (CHS) with the novel antigen dipheny...
Medical Oncology Group of Australia, Pierre Fabre Cancer Achievement Award: Papillomavirus specific immunity as a means to prevent deaths from cervical cancer
Medical Oncology Group of Australia Pierre Fabre Cancer Achievement Award Papillomavirus specific immunity as a means to prevent deaths from cervical cancer
2015/3/24
Cervical cancer was shown by Professor Harald zur Hausen in the early 1980s to be initiated by infection of cervical epithelium with certain human papillomaviruses, now designated as “high risk” papil...
Increasing The Rate Of Pertussis Immunity Using The Tdap Immunization In Primary Care Patients 19 To 64 Years Of Age
Tdap Family Practice Immunity of Pertussis
2014/10/22
There has been an increase in the preventable communicable disease known as Pertussis as the result of waning immunity in adolescents and adults. Waning immunity is the loss of protective antibodies o...
Rubella Immunity in Women of Childbearing Age, Eight Years After the Immunization Program in Iran
Rubella Congenital Rubella Syndrome Immunity Vaccination
2015/10/13
Background: Rubella is a viral disease with a worldwide distribution. Mass vaccination campaigns have increased the vaccine coverage in the world with substantial impact on reduction of rubella infect...
Rubella Immunity in Women of Childbearing Age, Eight Years After the Immunization Program in Iran
Rubella Congenital Rubella Syndrome Immunity Vaccination
2015/10/13
Background: Rubella is a viral disease with a worldwide distribution. Mass vaccination campaigns have increased the vaccine coverage in the world with substantial impact on reduction of rubella infect...
CD4+ T cell mediated tumor immunity following transplantation of TRP-1 TCR gene modified hematopoietic stem cells
Melanocyte Differentiation Antigen Lentiviral Vectors
2015/5/21
Immunotherapy for cancer has held much promise as a potent modality of cancer treatment. The ability to selectively destroy diseased cells and leave healthy cells unharmed has been the goal of cancer ...
Reliability of self-reported history in predicting immunity against measles, rubella, mumps, and varicella among health care workers
Measles rubella mumps varicella seroprevalence health care worker
2010/12/21
To determine the immunity of health care workers (HCWs) against measles, rubella, mumps, and varicella infections, and to evaluate the reliability of self-reported history of the disease in predicting...
Reliability of self-reported history in predicting immunity against measles, rubella, mumps, and varicella among health care workers
Measles rubella, mumps, varicella seroprevalence health care worker
2010/11/22
To determine the immunity of health care workers (HCWs) against measles, rubella, mumps, and varicella infections, and to evaluate the reliability of self-reported history of the disease in predicting...
The Inflammasome, an Innate Immunity Guardian, Participates in Skin Urticarial Reactions and Contact Hypersensitivity
contact hypersensitivity IL-1β inflammasome NLRP3 urticaria
2010/11/12
Urticarial rash, one of the clinical manifestations characteristic of cryopyrin-associated periodic syndrome (CAPS), is caused by a mutation in the gene encoding for NLRP3 (nucleotide-binding oligomer...