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Excess iron: considerations related to development and early growth
brain early growth erythropoiesis excess iron iron metabolism ron toxicity pregnancy stem cells
2018/11/21
What effects might arise from early life exposures to high iron? This review considers the specific effects of high iron on the brain, stem cells, and the process of erythropoiesis and identifies gaps...
Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4–5 y of age: the prospective birth cohort Infancia y Medio Ambiente (INMA) study
folic acid supplements folate pregnancy periconception period child neurocognitive development
2018/11/16
Background: The benefits of the use of folic acid supplements (FASs) during the periconception period to prevent neural tube defects and to ensure normal brain development in offspring are well known....
Using the Loess Method to Describe the Effect of Temperature on Development Rate
non-parametric model local regression weighted least squares Aphididae
2018/3/5
Temperature has a significant influence on development rates of insects and mites. Many parametric models were
built to describe the temperature-dependent development rates. However, these models pro...
The role of gluten consumption at an early age in celiac disease development: a further analysis of the prospective PreventCD cohort study
celiac disease children gluten HLA European cohort
2018/11/13
Background: We previously found that the introduction of small quantities of gluten at 4–6 mo of age did not reduce the risk of celiac disease (CD) in a group of high-risk children. However, the consu...
Development and application of LC/HRPS for quantification of adenine nucleotides,creatine phosphate,and creatine in sturgeon spermatozoa
macroergic phosphates high resolution mass spectrometry extraction method validation sperm chondrostean fishes
2017/2/21
The objective of this study was to investigate the applicability of liquid chromatography coupled with high resolution product scan (LC/HRPS) mass spectrometry for simultaneous quantification of adeni...
Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development
birth defects developmental defects embryo folic acid high folate methylenetetrahydrofolate reductase MTHFD1 placenta
2018/12/19
Background: Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and fetus. Common polymorphisms in folate genes, such as methylenetetrahydro...
Suggested use of sensitive measures of memory to detect functional effects of maternal iodine supplementation on hippocampal development
hippocampus infant neurodevelopment iodine status memory thyroid hormone
2018/12/14
Maternal hypothyroxinemia secondary to iodine deficiency may have neurodevelopmental effects on the specific neurocognitive domain of memory. Associated disruption of thyroid hormone–dependent protein...
Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study
BMI children genetics international comparisons twins
2018/12/3
Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking.
Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study
BMI children genetics international comparisons twins
2018/12/13
Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking.
Development of a Novel, Anti-idiotypic Monoclonal Anti-prolactin Antibody That Mimics the Physiological Functions of Prolactin
Prolactin Anti-idotypic Antibody Signal Transduction
2016/5/20
In this work, we prepared a panel of monoclonal anti-idiotypic antibodies to ovine prolactin (oPRL) by the hybridoma technique. Among these antibodies, one anti-idotypic antibody (designated B7) was c...
Identification of Histone Deacetylase 2 as a Functional Gene for Skeletal Muscle Development in Chickens
Histone Deacetylas Post Genome-Wide Association Study Gene Expression Myogenesis
2016/5/19
A previous genome-wide association study (GWAS) exposed histone deacetylase 2 (HDAC2) as a possible candidate gene for breast muscle weight in chickens. The present research has examined the possible ...
Differential Expression of Genes Important to Efferent Ductules Ion Homeostasis across Postnatal Development in Estrogen Receptor-慣 Knockout and Wildtype Mice
P450 Aromatase Estrogen Epithelial Ion Transporters
2016/4/27
Our earlier studies showed that estrogen was involved in the regulation of fluid reabsorption in adult mouse efferent ductules (ED), through estrogen receptor (ER) ??and ER?? by modulating gene expres...
Effects of maternal and child lipid-based nutrient supplements on infant development: a randomized trial in Malawi
cognitive development iLiNS project infant development lipid-based nutrient supplements maternal micronutrient supplements
2018/11/28
Background: Maternal and infant undernutrition is associated with poor infant development; however, few studies have examined the impact of combined pre- and postnatal dietary supplementation on infan...
Learning-Related Development of Context-Specific Neuronal Responses to Places and Events:The Hippocampal Role in Context Processing
hippocampus context learning place cell interneuron episodic memory
2015/8/7
Contextual information plays a key role in learning and memory. Learned information becomes associated with the context such that the context can cue the relevant memories and behaviors. An extensive ...
Complex Systems Analysis of Arrested Neural Cell Differentiation during Development and Analogous Cell Cycling Models in Carcinogenesis
Cell cycling control of cell division and the neoplastic transformation in carcinogenesis essential roles of high c-Myc p27 Inhibition p53 inactivation and hTERT activation of Telomerase biosynthesis in Malignant Cell Transformation Rational Clinical trials Individualized Medicine and potential for optimized Radio-Chemo- Gene- and Immuno- therapies of Cancers Ł ukasiewicz models of Genetic Networks Genome and cell interactomics models in terms of categories of Ł ukasiewicz logic Algebras and Lukasiewicz Topos Ł ukasiewicz Topos with an n-valued Ł ukasiewicz Algebraic Logic subobject classifier genetic network transformations in Carcinogenesis developmental processes and Evolution/ Evolutionary Biology Relational Biology of Archea yeast and higher eukaryotic organisms nonlinear dynamics in non-random hierarchic genetic networks proteomics coupled genomes via signaling pathways mechanisms of neoplastic transformations of cells and topological grupoid models of genetic networks in cancer cells natural transformations of organismic structures in Molecular Biology
2015/7/30
A new approach to the modular, complex systems analysis of nonlinear dynamics of arrested neural cell Differentiation--induced cell proliferation during organismic development and the analogous cell c...