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Poisson-PDNN: Modeling non-uniform read distribution in RNA-seq data
Poisson-PDNN Modeling non-uniform distribution in RNA-seq data
2016/1/25
RNA-Seq is a powerful new technology to comprehensively analyze the transcriptome of any given cells. An important task in RNA-Seq data analysis is quantifying the expression levels of all transcripts...
Backgroud: Epistatic Miniarray Profiles (EMAP) enables the research of genetic interaction as an importan-t method to construct large-scale genetic interaction network. However, high proportion of mis...
On Smoothing Estimation For Seasonal Times Series With Long Cycles
Large deviation Large p, small n Optimal detection boundary Sparse signal Thresholding Weak dependence
2016/1/25
We consider two alternative tests to the Higher Criticism test of Donoho and Jin (2004) for high dimensional means under the spar-sity of the non-zero means for sub-Gaussian distributed data with unkn...
Central Limit Theorems for Supercritical Superprocesses
Central limit theorem supercritical superprocess excursion measures of superprocesses
2016/1/25
In this paper, we establish a central limit theorem for a large class of general supercritical superprocesses with spatially dependent branching mechanisms satisfying a second moment condition. This c...
Optimal Reinsurance under Distortion Risk Measures
Distortion risk measure expected premium principle the optimal reinsurance strategy VaR TVaR
2016/1/25
In this paper, we discuss the optimal reinsurance strategy of minimizing the in-surer’s risk under the distortion risk measure. We assume that reinsurance premium is determined by the expected premium...
Classify hyperdiploidy status of multiple myeloma patients using gene expression profiles
Classify hyperdiploidy status multiple myeloma patients expression profiles
2016/1/25
Multiple myeloma (MM) is a cancer of antibody-making plasma cells. It frequently harbors alterations in DNA and chromosome copy numbers, and can be divided into two major subtypes, hyperdiploid (HMM) ...
The shaping and functional consequences of the dosage effect landscape in multiple myeloma
shaping functional consequences dosage effect landscape multiple myeloma
2016/1/25
In this paper we study the conditional limit theorems for critical continuous-state branching processes with branching mechanism ψ(λ) = λ 1+α L(1/λ)where α ∈ [0,1] and L is slowly varying at ∞. We pro...
Closed-form expansions of discretely monitored asian options in diffusion models
discretely monitored Asian options CEV model CIR process Black-Scholes model Brennan
2016/1/25
In this paper we propose a closed-form asymptotic expansion approach to pricing discretely monitored Asian options in general one-dimensional diffusion models. Our expansion is a small-time expansion ...
Marginal empirical likelihood and sure independence screening
Empirical likelihood high dimensional data analysis independence sure screening large deviation
2016/1/25
We study a marginal empirical likelihood approach in scenarios when the num-ber of variables grows exponentially with the sample size. The marginal empirical likelihood ratios as functions of the para...
canEvolve: A web portal for integrative oncogenomics
canEvolve web portal integrative oncogenomics
2016/1/25
Genome-wide profiles of tumors obtained using functional genomics platforms are being deposited to the public repositories at an astronomical scale, as a result of focused efforts by individual labora...
Central Limit Theorems for Supercritical Branching Markov Processes
Central limit theorem branching Markov process supercritical mar- tingale eigenfunction expansion
2016/1/25
In this paper we establish spatial central limit theorems for a large class of supercritical branching Markov processes with general spatial-dependent branching mechanisms. These are generalizations o...
Estimation of fixed effects panel regression models with separable and nonseparable space-time filters
Panel data Spatial cointegration Explosive roots Fixed e¤ects
2016/1/25
This paper considers a quasi-maximum likelihood estimation for a linear panel data model with time and individual …xed e¤ects, where the disturbances have dynamic and spatial correlations which might ...
Transcription factor-pathway co-expression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma
coexpression cell cycle arrest multiple myeloma hyperdiploid
2016/1/25
Multiple myeloma is a hematological cancer of plasma B cells and remains incurable. Two major subtypes of myeloma, hyperdiploid MM (HMM) and non-hyperdiploid MM (NHMM), have distinct chromosomal alter...
High dimensional stochastic regression with latent factors, endogeneity and nonlinearity
α-mixing dimension reduction instrument variables nonstationarity time series
2016/1/25
We consider a multivariate time series model which represents a high dimensional vector process as a sum of three terms: a linear regression of some observed regressors,a linear combination of some la...
Testing Covariates in High Dimensional Regression
Generalized Linear Model High Dimensional Data Hypothe- ses Testing
2016/1/25
In a high dimensional linear regression model, we propose a new procedure for testing statistical significance of a subset of regression coefficients. Specifically,we employ the partial covariances be...