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Effect of MK-906, a specific 5 alpha-reductase inhibitor, on serum androgens and androgen conjugates in normal men
MK-906 5 alpha-reductase inhibitor serum androgens androgen conjugates normal men
2009/2/23
To determine the hormonal effects of MK-906, an orally active 5 alpha-reductase inhibitor, on serum androgens and androgen conjugates, 12 healthy men were given 10, 20, 50, and 100 mg MK-906 2 weeks a...
Nature of alpha subunit secretion in men:circadian rhythms, pulsatile release and secretory profiles
alpha subunit secretion men circadian rhythms pulsatile release secretory profiles
2009/2/23
Alpha subunit complements LH as a marker of the activity of the hypothalamic GnRH pulse generator. To characterize episodes of alpha subunit release and to determine if a circadian pattern of alpha ...
Kinetics of secretion of luteinizing hormone subunits and free alpha, and effects of gonadotropin releasing hormone
luteinizing hormone subunits gonadotropin releasing hormone
2009/2/23
While GnRH is known to stimulate release of pituitary gonadotropins, its acute effects on the kinetics of secretion of the various hormones and subunits are not well characterized. Pulse-chase exp...
Chronic ethanol ingestion during puberty alters the transient increase in testicular 5 alpha-reductase in the Swiss-Webster mouse
transient increase testicular 5 alpha-reductase Swiss-Webster mouse
2009/2/23
Previous experiments with inbred mice showed that chronic ethanol treatment delays male pubertal development. An initial event in sexual maturation in the rat is a transient increase in 5 alpha-re...
Alpha-glucosidase as a specific epididymal enzyme marker. Its validity for the etiologic diagnosis of azoospermia
azoospermia epididymal marker aglucosidase carnitine obstructive pathology
2009/2/23
Azoospermic semen was obtained from 39 vasectomized men and 93 patients consulting for infertility. The latter underwent bioclinical investigations including measurement of plasma FSH and testicular...
Receptor-mediated endocytosis of alpha 2-macroglobulin by principal cells in the proximal caput epididymidis in vivo
alpha 2-macroglobulin principal cells proximal caput epididymidis
2009/2/20
Micropuncture techniques were used to study receptor-mediated endocytosis of alpha 2-macroglobulin bound to colloidal gold (alpha 2M-gold) by principal cells in the proximal caput epididymidis of co...
Similar biochemical properties of human seminal plasma and epididymal alpha-1,4-glucosidase
1-4 glucosidase seminal plasma epididymis
2009/2/20
We have studied some characteristics of alpha-1,4-glucosidases in human male reproductive organs in order to obtain information on the origin of the enzyme in seminal plasma. Acid and neutral enzyme...
Inhibition of 5 alpha-reductase activity and alteration of nuclear testosterone.
5a-reductase fibroblast androgen receptor enzyme inhibitor nuclear uptake
2009/2/20
17 beta-N, N-diethylcarbamoyl-4-methyl-4-aza-5 alpha-androstan-3-one (4-MA) inhibits 5 alpha-reductase activity in cultured human genital skin fibroblasts. Enzyme kinetic studies analyzed by Eadie...
The male antifertility agents alpha chlorohydrin, 5-thio-D-glucose, and 6-chloro-6-deoxy-D-glucose interfere with sugar transport across the epithelium of the rat caput epididymidis
rat epididymis sugar transport antifertility
2009/2/19
The effects of the male antifertility agents alpha-chlorohydrin, 5-thio-D-glucose, and 6-chloro-6-deoxy-D-glucose on sugar transport (3H-3-O-methyl-D-glucose and 3H-2-deoxy-D-glucose) across the r...
A pilot study demonstrating clinical benefit from intralesional interferon alpha 2B in the treatment of Peyronie's disease
Nonsurgical therapy intralesional IFN-a-2B
2009/2/18
Intralesional therapy is a less invasive method for the treatment of Peyronie's disease. The objective of this study was to evaluate intralesional injections of interferon alpha 2B (IFN-alpha-2B) ...
The classic testicular tumor marker alpha-fetoprotein (AFP) is associated with nonseminomatous germ cell tumors, including embryonal carcinoma, yolk sac tumor, and teratoma. AFP is not considered to...
The loss of alpha-adrenergic effect during the erectile response in the long-term diabetic rat
Diabetic rats erectile response nitroglycerin phenylephrine
2009/2/17
The present study was designed to investigate the effect of long-term, streptozotocin-induced diabetes on the erectile response in the laboratory rat. Mean arterial blood pressure (MAP) and intracav...
Sperm motion predicts fertility in male hamsters treated with alpha-chlorohydrin
Sperm motion predicts fertility male hamsters alpha-chlorohydrin
2009/2/17
An understanding of the relationship between altered sperm motion and sperm function (fertility) is important when interpreting the biological significance of toxicant-induced changes in sperm veloc...
Estrogen receptor(alpha and beta)expression in the excurrent ducts of the adult male rat reproductive tract
Efferent ductules immunohistochemistry
2009/2/17
The understanding of estrogen's function in the male reproductive tract is limited, and estrogen receptor (ER) localization in the reproductive tract of the adult male rat has not been described. ...
Differential methylation in steroid 5 alpha-reductase isozyme genes in epididymis, testis, and liver of the adult rat
Gene methylation gene expression androgens dihydrotestosterone eukaryotic adenine methylation
2009/2/17
DNA methylation has been largely involved in the regulation of tissue-specific gene expression. The aim of the study was to determine the methylation pattern of steroid 5 alpha-reductase genes 1 and 2...