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Heart and Brain Tissue Banks for Research on Co-Occurring Cardiovascular and Neurological/Psychiatric Disorders
Cardiovascular Neurological/Psychiatric Disorders
2009/9/3
Epidemiological studies point to a strong and possibly causal association of psychiatric and neurological disorders with cardiovascular disease (CVD). Mechanistic links between these co-occurring illn...
P2X7 Receptors in Neurological and Cardiovascular Disorders
Neurological Cardiovascular Disorders
2009/9/3
P2X receptors are ATP-gated cation channels that mediate fast excitatory transmission in diverse regions of the brain and spinal cord. Several P2X receptor subtypes, including P2X7, have the unusual p...
P2X7 Receptors as a Transducer in the Co-Occurrence of Neurological/Psychiatric and Cardiovascular Disorders: A Hypothesis
P2X7 Receptors Neurological/Psychiatric
2009/9/3
Background. Over-stimulation of the purinergic P2X7 receptor may bring about cellular dysfunction and injury in settings of neurodegeneration, chronic inflammation, as well as in psychiatric and cardi...
Putative Role of MicroRNA-Regulated Pathways in Comorbid Neurological and Cardiovascular Disorders
MicroRNA-Regulated Pathways Comorbid Neurological
2009/9/3
Background. The conserved noncoding microRNAs (miRNAs) that function to regulate gene expression are essential for the development and function of the brain and heart. Changes in miRNA expression prof...