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心脑血管疾病(CVD)是全世界人口死亡的主要原因之一。85%的CVD相关死亡是由于心脏病发作和脑中风导致。动脉粥样硬化引发动脉管腔狭窄导致心脏病发作和脑中风。前期，中国科学院遗传与发育生物学研究所张永清研究员团队与北京希诺谷生物技术公司和首都医科大学吉训明教授等团队合作在SCIENCE CHINA Life Sciences发表了Dogs lacking Apolipoprotein E show...
21 days of mammalian omega-3 fatty acid supplementation improves aspects of neuromuscular function and performance in male athletes compared to olive oil placebo
Omega-3 fatty acids Neuromuscular function Fat supplementation Performance Adaptations to training
2015/7/30
Omega-3 polyunsaturated fatty acids (N-3) are essential nutrients for human health and integral components of neural tissues. There is evidence that N-3 supplementation may benefit exercise performanc...
Evolution of the redox function in mammalian Apurinic/ apyrimidinic endonuclease
APE1 redox evolutionary analysis
2014/12/12
Human apurinic/apyrimidinic endonuclease (hApe1) encodes two important functional activities: an essential base excision repair (BER) activity and a redox activity that regulates expression of a numbe...
Yeast apurinic/apyrimidinic endonuclease Apn1 protects mammalian neuronal cell line from oxidative stress
DNA repair gene therapy
2014/12/12
Reactive oxygen species (ROS) have been implicated as one of the agents responsible for many neurodegenerative diseases. A critical target for ROS is DNA. Most oxidative stress-induced DNA damage in t...
Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells
APE1/Ref-1 cell signaling difference analysis
2014/12/12
Apurinic apyrimidinic endonuclease/redox effector factor 1 (APE1/Ref-1) protects cells from oxidative stress by acting as a central enzyme in base excision repair pathways of DNA lesions and through i...