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Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress; Use of APE1 small molecule inhibitors to delineate APE1 functions
base excision repair APE1/Ref-1 oxidative stress
2014/12/12
Oxidative DNA damage has been implicated in a number of central nervous system pathologies. The base excision repair (BER) pathway is one of the most important cellular protection mechanisms that resp...
Small-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation
Ape1 inhibitor base excision repair biomarkers
2014/12/12
There has been a recent upsurge in the development of small-molecule inhibitors specific to DNA repair proteins or proteins peripherally involved in base excision repair and the DNA damage response. T...
Quality of Life in Hemophilia Complicated by Inhibitors
Quality Hemophilia Complicated Inhibitors
2015/9/25
Inhibitors in patients with hemophilia are a rare complication which leads to pain, disability and impairment in quality of life. Recent advances in treatment have improved this situation, doubtful of...
Glycoprotein IIb/IIIa Inhibitors in Acute Coronary Syndromes: A new Paradigm in Cardiology
Coronary Syndromes Cardiology Glycoprotein
2009/7/2
Acute coronary syndromes, namely, unstable angina and myocardial infarction, remain a major cause of morbidity and mortality (1). The light has been shed on the pathogenesis of these syndromes by rece...
Serum Transforming Growth Factor-β (TGF-β), Matrix Metalloproteinase-2 (MMP-2), Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitors of Metalloproteinase (TIMP-1) Levels in Childhood Asthma
Asthma children metalloproteinase airway remodelling
2009/6/16
Aims: Airway remodelling is a characteristic feature of asthma and is a dynamic process involving extracellular matrix (ECM) production and its degradation. In this regard, the matrix metalloproteinas...
Inhibition of corneal neovascularization with new Tyrosine Kinase Inhibitors targeting vascular endothelial growth factor receptors:Sunitinib malate and Sorafenib
Cornea Sunitinib malate Sorafenib
2010/4/16
Corneal neovascularization (NV) is a significant, sight-threatening, complication of many ocular surface disorders. Presence of new vessels in cornea can compromise clarity and thus vision. The data s...
Inhibition of tracheal smooth muscle cell proliferation by phosphodiesterase inhibitors
phosphodiesterase inhibitors proliferation tracheal smooth muscle cells
2010/11/29
Agents that increase intracellular cyclic 3',5'-adenosine monophosphate (cAMP), such as forskolin, prostaglandin (PG)E2, salbutamol and 8-bromo-cAMP, have been shownto inhibit the proliferation of air...
