搜索结果: 1-15 共查到“基础医学 Polymorphism”相关记录16条 . 查询时间(0.143 秒)
Tumor Necrosis Factor-Alpha Polymorphism and Susceptibility to Multiple Sclerosis in the Iranian Population
Tumor Necrosis Factor-Alpha Multiple Sclerosis Sclerosis
2015/10/16
Background: Multiple sclerosis (MS) is an immune-mediated disease of polygenic etiology. Tumor necrosis factor-α (TNF-α) microsatellite as a proinflammatory cytokine is believed to play an important r...
汕头大学医学院药理学课件 gene polymorphism and drug and disease[1]
汕头大学医学院 药理学 课件 gene polymorphism and drug and disease[1]
2014/6/25
汕头大学医学院药理学课件 gene polymorphism and drug and disease[1]。
HER2 Ile655Val Single Nucleotide Polymorphism in Patients with Ovarian Cancer
Carcinoma Endometrioid HER2 Polymorphism Single Nucleotide
2015/9/29
Background: The association between HER2 Ile655Val single nucleotide polymorphism and cancer is controversial.
Association between MDR1 C3435T Gene Polymorphism and Acute Lymphoblastic Leukemia (ALL) in Iranian Population
P-glycoprotein MDR1 Acute lymphoblastic leukemia C3435T polymorphism
2015/9/21
Background: P-glycoprotein (P-gp), an ATP-dependent efflux pump, is a membrane protein encoded by MDR1 gene. P-gp has an important role in protection of the cell against xenobiotics and toxic compound...
Single Strand Conformation Polymorphism analysis of PCR-amplified rDNA to differentiate medically important Aspergillus Species
SSCP Aspergillus Identification PCR
2009/12/9
Background: Aspergillus species are associated with allergic bronchopulmonary disease, mycotic keratitis, otomycosis, nasal sinusitis and invasive infection. In this study, we developed a PCR-Sin...
Association of Methylenetetrahydrofolate Reductase gene Polymorphism (C677T) with Metabolic Syndrome in an Iranian Population: Tehran Homocysteine Survey
MTHFR Metabolic syndrome Population
2009/11/26
Background: The association of MTHFR and metabolic syndrome (MS) has been shown in special groups of diabetic and schizophrenic subjects, but no single study has investigated this relation in metaboli...
emm Gene Polymorphism among Streptococcus pyogenes Isolated from Throat Culture
Streptococcus pyogenes PCR- RFLP emm gene Pharyngitis
2009/11/26
DNA sequencing is the most conclusive method for emm (M protein gene) typing of Streptococcus pyogenes. This method is not a feasible approach in developing countries where streptococcal infection is ...
The Frequency of CCR5delta32 Polymorphism in the Central Black Sea Coastal Region in a Healthy Population
Chemokine receptor delta32 Turkish people
2009/6/17
Aim:Delta32 polymorphism in the chemokine receptor 5 (CCR5) gene affects human immune deficiency virus type 1 (HIV-1) entry, transmission, and outcome. The aim of this study was to determine the allel...
组织蛋白酶D基因C224T多态与散发阿尔茨海默氏病的关联研究The C224T Polymorphism in the Cathepsin D Gene is not Associated with Sporadic Alzheimer’s Disease in Chinese
阿尔兹海默氏病 组织蛋白酶基因 多态性 限制性片段长度
2008/1/10
摘要
组织蛋白酶D（Cathepsin D）是一种细胞核内体/溶酶体内的门冬酰胺蛋白酶。它有可能通过剪切淀粉样前体蛋白参与阿尔茨海默氏病（Alzheimer’s disease, AD）相关的神经退化。在以德国人为对象中的研究显示组织蛋白酶D基因（CTSD）C224T多态与AD发病风险紧密相关。然而，此结果未能在另一些群体中得到重复。为此，我们通过聚合酶链反应-限制性片段长度多态性方法分析了C...
山东胃癌高低发人群Lewis基因多态性分析Analysis of Lewis Gene Polymorphism in High and Low Incidence Area of Gastric Cancer in Shandong Province
胃癌 高低发人群 Lewis基因多态性
2007/12/30
摘要应用PCR产物直接测序的方法，检测山东省胃癌高发的临朐人群和低发的苍山人群中Lewis基因多态性T59G的分布,旨在探讨山东临朐和苍山地区胃癌发病率显著不同的内在原因，为阐明临朐地区胃癌高发的机制提供实验依据。结果表明,T59G突变个体在临朐和苍山人群中的分布频率分别为34.5%和31.6%，差别无统计学意义，P＞0.05,OR为1.14 （95% CI,0.59~2.19）。提示就此点突变而...
Graves病患者TNFβ基因微卫星多态性分析Analysis of TNFβ Gene Microsatellite Polymorphism in Graves Disease
淋巴毒素 微卫星多态性 格雷夫斯病
2007/12/7
摘要为研究Graves病患者（简称GD）TNF（tumor necrosis factor）β基因内含子1的微卫星多态性（TNFc）,应用聚合酶链反应（PCR）技术和聚丙烯酰胺凝胶电泳分析Graves病实验组和正常对照组的基因频率和基因型频率。结果可见，TNFc微卫星多态性含有两个等位基因及3种基因型，Graves病实验组的TNFc2基因频率高于正常对照组，有显著性差异 （χ2=4.02，P＜0....
Population Polymorphism of Trypanosoma cruzi in Latin America indicated by Proteome analysis and by in vitro amastigote proliferation
Trypanosoma cruzi Two-dimensional gel electrophoresis
2010/12/10
Nineteen stocks of Trypanosoma cruzi originating from several endemic countries for Chagas‘ disease in Central and South America were subjected to two-dimensional protein electrophoresis analysis. The...
Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T Polymorphism Is Associated with Coronary Atherosclerosis Disease in a Sample of Iranian Patients
MTHFR CAD Folate Folic acid Homocysteine
2010/4/6
Background: Several studies showed that elevated plasma homocysteine level is a risk factor for coronary artery disease (CAD). A common polymorphism C677T of methylenetetrahydrofolate reductase (MTHFR...
Association between the Polymorphism of TGF-β1 Gene Promoter (-509C>T) and Idiopathic Chronic Urticaria
Polymorphism TGF-1 gene Urticaria
2010/2/1
Idiopathic Chronic Urticaria (ICU), the most common form (70-80%) of chronic urticaria is supposed to have immune basis causes. It is speculated that the promoter polymorphism of TGF-β1 gene may be in...
Lack of Association between Atopic Dermatitis and -401A/G Polymorphism in the Promoter Region of the RANTES Gene in Japanese
atopic dermatitis IgE polymorphism RANTES
2010/11/22
Background: Regulated on activation, normal T expressed and secreted (RANTES) has been known to be deeply involved in the pathophysiology of atopic dermatitis (AD). To examine whether a -401A/G polymo...