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Implantable devices that release insulin into the body hold promise as an alternative way to treat diabetes without insulin injections or cannula insertions.
抑制缝隙连接预防药物性肝毒性和爆发性肝功能衰竭（Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure）
抑制缝隙 预防药物性 肝毒性 爆发性 肝功能衰竭
2012/2/1
Drug-induced liver injury (DILI) limits the development and application of many therapeutic compounds and presents major challenges to the pharmaceutical industry and clinical medicine. Acetaminophen-...
Selective cyclooxygenase-2 inhibition prevents bone resorption
Alveolar bone loss Anti-inflammatory agents,non-steroidal Cyclooxygenase inhibitors Periodontitis Radiography dental
2009/10/19
The aim of the present work was to evaluate the effect of a selective cyclooxygenase-2 (COX-2) inhibitor (meloxicam) on the alveolar bone loss progression in experimentally induced periodontitis. Fort...
Endogenous and Exogenous Thioredoxin 1 Prevents Goblet Cell Hyperplasia in a Chronic Antigen Exposure Asthma Model
airway remodeling asthma goblet cell thioredoxin
2010/11/16
Goblet cell hyperplasia with mucus hypersecretion contribute to increased morbidity and mortality in bronchial asthma. We have reported that thioredoxin 1 (TRX1), a redox (reduction/oxidation)-active ...
Alendronate Prevents Alveolar Bone Loss in Experimental Rat Periodontitis
alendronate alveolar bone resorption experimental rat periodontitis micro CT
2009/5/21
Alendronate, a nitrogen-containing bisphosphonate, strongly inhibits bone loss and is administered to osteoporosis patients. Because periodontitis also demonstrates excessive alveolar bone resorption,...
N-hexacosanol prevents diabetes-induced rat ileal dysfunction without qualitative alteration of the muscarinic receptor system
N-hexacosanol diabetes-induced rat qualitative alteration muscarinic receptor system
2009/3/2
We evaluated the effects of N-hexacosanol, a cyclohexenonic long-chain fatty alcohol, on muscarinic receptors in diabetic rat ileal dysfunction. Eight-week-old male SD rats were divided into four gr...
Brain-derived neurotrophic factor（BDNF）prevents the development of diabetes in prediabetic mice
Brain-derived neurotrophic factor (BDNF) diabetes prediabetic mice
2009/3/2
We previously reported that peripheral injection of brain-derived neurotrophic factor (BDNF) exhibits hypophagic and hypoglycemic effects in obese hyperglycemic animals, indicating its antiobesi...
Trisialoganglioside GT1b Prevents Increase in Sperm Membrane Molecular Ordering Induced by In Vitro Lipid Peroxidation
Membrane rigidity gangliosides spermatozoa
2008/12/23
The effect of various types of gangliosides, the sialic acid-containing glycosphingolipids, on human sperm membrane during lipid peroxidation induced by Fe2+/ascorbate ions was investigated. The m...
Neonatal Coadministration of Testosterone With Diethylstilbestrol Prevents Diethylstilbestrol Induction of Most Reproductive Tract Abnormalities in Male Rats
Rete testis efferent ducts vas deferens seminal vesicles androgens estrogens
2008/12/19
The primary purpose of this study was to evaluate whether the coadministration of testosterone (TE; 200 µg) with 10 µg of diethylstilbestrol (DES) between days 2 and 12 postnatally could...
FDA Approves Novel Device That Prevents or Reduces Brain Damage in Infants
hypoxic-ischemic encephalopathy Cool-Cap system Infants
2006/12/26
December 20, 2006，The Food and Drug Administration (FDA) today approved a first-of-a-kind medical device for the treatment of babies born with moderate to severe hypoxic-ischemic encephalopathy (HIE),...
Nerve Growth Factor Prevents Demyelination, Cell Death and Progression of the Disease in Experimental Allergic Encephalomyelitis
Experimental allergic encephalomyelitis Myelin Nerve growth factor Spinal cord
2010/2/8
Experimental allergic encephalomyelitis (EAE), a demyelinating disease induced in the animals parallels multiple sclerosis in human in several aspects, provides a useful model to investigate multiple ...
The Phosphodiesterase 4 Inhibitor Prevents Antigen-induced Biphasic Nasal Obstruction in Brown Norway Rats
acoustic rhinometry allergic rhinitis BN rat nasal obstruction PDE inhibitor
2010/11/22
Background: Nasal obstruction is considered the most serious problem for patients with allergic rhinitis. We have previously established a model of nasal obstruction in guinea pigs. In the present stu...
Oligomeric but not monomeric silica prevents aluminum absorption in humans
Oligomeric silica monomeric silica, orthosilicic acid silicon silicic acid silica aluminum absorption, bioavailability gastrointestinal uptake accelerator mass spectrometry
2016/6/3
Background: Soluble silica, a ubiquitous component of the diet,
may be the natural ligand for dietary aluminum and may prevent
its accumulation and toxicity in animals. However, previous
studies on...
Dietary medium-chain triacylglycerol prevents the postprandial rise of plasma triacylglycerols but induces hypercholesterolemia in primary hypertriglyceridemic subjects
Medium-chain triacylglycerol corn oil, hypertriglyceridemia hypercholesterolemia lipoprotein metabolism, test meal nonobese adults
2016/6/3
Background: Previous studies showed divergent results concerning
the influence of medium-chain triacylglycerol (MCT) on
lipoprotein metabolism.
Objective: The objective of this study was to compare...
