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离子通道是一类跨膜的大分子孔道,可允许离子在电化学梯度驱动下穿过细胞膜,从而完成信号传导、细胞兴奋性调节等生理功能,现已成为当前药物研发中仅次于G蛋白偶联受体、蛋白激酶的第三大类药物靶点。
汕头大学医学院药理学精品课程 Calcium Channel Blockers (CCB)。
The fundamental problem of denoising and deblurring images is addressed in this study. The great difficulty in this task is due to the ill-posedness of the problem. We analyze multi-channel images to ...
The fundamental problem of denoising and deblurring images is addressed in this study. The great difficulty in this task is due to the ill-posedness of the problem. We analyze multi-channel images to ...
Chloride channel Myotonia is a form of channelopathy, and Myotonia is its manifestation. Myotonia may be defined as delayed relaxation of skeletal muscle after its contraction. Decreased chloride cond...
Various diester analogues of nifedipine in which the ortho nitrophenyl group at position 4 were replaced by 3-chloro-1H-2-indolyl substituent, were synthesized and evaluated as calcium antagonists on ...
The discovery that 1,4-dihydropyridine (DHP) class of calcium channel antagonist inhibits the Ca+² influx represented a major therapeutic advance in the treatment of cardiovascular diseases such ...
A group of racemic 3-[(2-hydroxyethyl), (2-Methoxyethyl), (2-acetylethyl) or (2-cyanoethyl)], 5- methyl, ethyl or isopropyl-1, 4-dihydro-2, 6-dimethyl-4-(1-methyl-5-nitro-2-imidazolyl)-3, 5-pyridinedi...
We describe a general framework for multi-channel image registration. A new similarity measure for registering two multi-channel images, each with an arbitrary number of channels, is proposed. Resul...
The epithelial Na+ channel (ENaC) contributes to control of blood pressure by reabsorbing Na+ in the cortical collecting duct of the kidney. The luminal Cl- concentration in the duct varies under phys...
The localization of the voltage-gated calcium channel (VGCC) α2 and the voltage-gated sodium channel (VGSC) α subunits was immunohistochemically investigated in chicken spinal motoneurons. Approximate...
Background and purpose of the study: The vasorelaxant action of the dihydropyridines (DHPs) provides many useful clinical indications. However, their negative effects on cardiac contractility is still...
A simple and sensitive kinetic spectrofluorometric method was developed for the determination of some calcium channel blockers namely, verapamil hydrochloride, diltiazem hydrochloride, nicardipine hyd...
Background: In order to prevent tumor metastasis, we investigated more effective inhibition by combination therapy. The competition with native adhesion molecules by cell-binding domain, inhibition of...

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