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Regulation of mTORC1 by growth factors,energy status,amino acids and mechanical stimuli at a g lance
mTORC1 Akt Myostatin Muscle protein synthesis
2016/5/16
The mechanistic/mammalian target of rapamycin c omplex 1 (mTORC1) plays a pivotal r ole in the regulation of skeletal muscle protein synthesis. A ctivation of the c omplex leads to phosphorylation of ...
Patients with the genetic disorder tuberous sclerosis complex (TSC) suffer from neoplastic growths in multiple organ systems. These growths are the result of inactivating mutations in either the TSC1 ...