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Interaction of an S100A9 gene variant with saturated fat and carbohydrates to modulate insulin resistance in 3 populations of different ancestries
gene-diet interaction insulin resistance SFA:carbohydrate ratio S100A9 gene type 2 diabetes
2018/12/13
Background: S100 calcium-binding protein A9 (S100A9) has previously been identified as a type 2 diabetes (T2D) gene. However, this finding requires independent validation and more in-depth analyses in...
人胰岛素基因在体内外表达的研究The Expression of Human Insulin Gene in vitro and in vivo
人胰岛素基因 基因治疗 肝细胞 糖尿病
2008/1/29
摘要利用定点突变人胰岛素基因，以脂质体载体和质粒不同比例形成的复合物进行体内外转染。体外转染鼠肝细胞，G418进行筛选，利用放免法测定培养液中胰岛素含量；体内通过肝门脉注射，测定模型鼠血糖及转染后7天时血液中胰岛素的含量，结果显示目的基因已转入肝细胞，且体内外转染都有一定量的成熟胰岛素表达，体外转染中质粒与脂质体比为1∶6转染后24h表达量最高为10.45μIU/ml，体内转染使模型鼠的糖尿病症状...