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【兴大报告632】A Personal Account on the Total Synthesis for Structural Validation of Natural Glycans and Glycoconjugates（图）
Natural Glycans Glycoconjugates Structural Validation
2023/6/20
报告人：俞飚 教授
中国科学院
Workshop 揈volutionary computation in computational structural biology?
Protein design computational biology
2016/7/19
In the last two decades, many computer scientists in Artificial Intelligence have made significant contributions to modeling biological systems as a means of understanding the molecular basis of mecha...
Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain
Humans Escherichia coli Benzamides Quinolines Nitriles Aniline Compounds Piperazines Pyrimidines Thiazoles Recombinant Proteins
2016/5/25
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein. The Abl inhibitors imatinib, nilotinib and dasatinib are currently used to treat CML, but resistance to t...
Ultrafast Excited-State Dynamics in the Green Fluorescent Protein Variant S65T/H148D.1.Mutagenesis and Structural Studies
Arabidopsis thaliana homogentisate phytyltransferase (HPT/VTE2) Lactuca sativa tocopherol tocopherol cyclase (TC/VTE1) vitamin e.
2016/5/24
Wild type green fluorescent protein (wt-GFP) and the variant S65T/H148D each exhibit two absorption bands, A and B, which are associated with the protonated and deprotonated chromophores, respectively...
Green Fluorescent Protein Variants as Ratiometric Dual Emission pH Sensors.1.Structural Characterization and Preliminary Application
Animals Cricetulus Cell Line Threonine Luminescent Proteins Green Fluorescent Proteins Microscopy, Confocal Crystallography, X-Ray Transfection Amino Acid Substitution
2016/5/24
Novel dual emission, pH-sensitive variants of the green fluorescent protein (GFP) have been constructed and are suitable for ratiometric emission measurements in vivo. This new class of GFPs, termed d...
19F NMR of Trifluoroacetyl-Labeled Cysteine Mutants of Myoglobin:Structural Probes of Nitric Oxide Bound to the H93G Cavity Mutant
19F NMR Trifluoroacetyl Cysteine Mutants Myoglobin Nitric Oxide H93G Cavity Mutant
2016/5/23
Nitric oxide (NO) binds to the myoglobin (Mb) cavity mutant, H93G, forming either a 5- or 6-coordinate Fe--NO heme complex. The H93G mutation replaces the proximal histidine of Mb with glycine, allowi...
On the Origin of Heme Absorption Band Shifts and Associated Protein Structural Relaxation in Myoglobin Following Flash Photolysis
transhydrogenase NAD NADP Escherichia coli proton pump metal ion
2016/5/23
The role of the protein structural change monitored by absorption band shifts following flash photolysis of CO from myoglobin is discussed in terms of structure-function relationships. Evidence is pre...
Excited State Energy Transfer Pathways in Photosynthetic Reaction Centers.1.Structural Symmetry Effects
biology and medicine,basic studies chemistry solar energy photosynthetic reaction centers energy transfer temperature dependence chemical reaction kinetics excited states molecular structure symmetry
2016/5/23
Ultrafast excited state energy transfer to the primary electron donor or special pair in photosynthetic reaction centers has been measured following excitation of the lowest electronic state of the ot...
A Structural Model for the Photosynthetic Reaction Center
Structural Model Photosynthetic Reaction Center
2016/5/20
We describe here the synthesis and characterization of the solution conformation of a molecule which brings into close proximity the principal molecular components believed to participate in the initi...
Structural changes between signaling states of bacterial chemoreceptors probed by solid -state NMR and hydrogen exchange
Structure of membrane protein lipid environment membrane signals bacteria chemical sensors membrane domains solid-state nuclear magnetic resonance (NMR)
2014/12/11
The limitations of structural studies of membrane proteins imposed by the lipid environment has made it difficult to determine the molecular mechanism of transmembrane signaling. For the bacterial che...
Structural and functional characterization of the unique N-terminus of Cse4p, A histone H3 -like protein at the S. cerevisiae centromere
Budding yeast the yeast protein protein fission yeast etc
2014/12/11
The budding yeast (S. cerevisiae) centromere component, Cse4p is an evolutionarily conserved histone H3-like protein, with homologues identified in fission yeast, worm, fly and human. All histone H3-l...
Functional tests of structural models for abortive cycling in T7 RNA polymerase
Pure sciences Biological sciences Abortive cycling RNA polymerase Transcription
2014/12/10
Transcription initiates when the enzyme binds to the promoter region and melts open an initial transcribing bubble that extends from position -4 to +4. The initiation phase continues until the enzyme ...
Structural studies of membrane-assembled PopD and PopB, the Pseudomonas aeruginosa type 3 secretion translocators
Pure sciences Biological sciences Fluorescence Membrane proteins Membranes Pore formation Type III secretion
2014/12/10
Transport of proteins across membranes is essential during many stages of pathogen infection and colonization of human cells. Many Gram-negative pathogens use a Type 3 Secretion (T3S) system to inject...
Structural And Biochemical Studies Of The Human Lysosomal Enzymes: N-Acetylgalactosamine-6-Sulfatase, N-Sulfoglucosamine Sulfohydrolase And Beta-Galactosidase
Pure sciences Biological sciences Cysteine modification Enzyme replacement therapy Lysosomal storage disease Pharmacological chaperone therapy Sulfatase structure X-ray crystallography
2014/12/10
Lysosomal storage diseases are disorders caused by deficiencies of enzymes responsible for the degradation of substances present in lysosomes. The loss of activity of a lysosomal enzyme leads to the a...
Structural Changes That Drive Timed Promoter Release In Transcription Reciprocally Lead To Abortive Instability
Biological sciences Aminopurine Abortive cycling Kinetics P266l Rna polymerase Transition Abortive instability
2014/12/10
RNA polymerases carry out a process, which at times carries contradictory mechanistic requirements. During initiation, an RNA polymerase should be highly sequence specific, binding only to and initiat...