搜索结果: 1-15 共查到“生物学 structural”相关记录41条 . 查询时间(0.14 秒)
朱卫国教授团队在《Nature Structural & Molecular Biology》发文揭示DNA损伤修复起始阶段染色质乙酰化的调控新机制（图）
DNA 朱卫国教授 生物学 赖氨酸
2023/10/23
DNA损伤应答与修复经历“进入-修复-恢复” (Access-Repair-Restore，ARR）三个生物学过程。核小体稳态对于DNA损伤应答及信号解除、基因转录瞬时激活与抑制至关重要。单就组蛋白赖氨酸乙酰化来说，乙酰化介导染色质松弛以便DNA修复推进或促进基因转录；去乙酰化则造成致密染色质结构以保护遗传物质不受损失或抑制基因转录，因此染色质松散被认为是DNA双链断裂修复（DSBs）的先决条件。...
AI system can generate novel proteins that meet structural design targets（图）
AI系统 新型蛋白质 可调蛋白质
2023/6/6
MIT researchers are using artificial intelligence to design new proteins that go beyond those found in nature.
【兴大报告632】A Personal Account on the Total Synthesis for Structural Validation of Natural Glycans and Glycoconjugates（图）
Natural Glycans Glycoconjugates Structural Validation
2023/6/20
报告人：俞飚 教授
中国科学院
More than 100 Cornell researchers from Cornell's Ithaca campus and Weill Cornell Medicine gathered for a two-day workshop in mid-October to discuss structural biology, which encompasses research explo...
Structural complexity in forests improves carbon capture（图）
Structural complexity forests carbon capture
2019/10/17
Forests in the eastern United States that are structurally complex -- the arrangement of vegetation is varied throughout the physical space -- sequester more carbon, according to a new study in Ecolog...
2018年SPIE生物系统和结构的健康监测会议（SPIE Health Monitoring of Structural and Biological Systems XII）
2018年 SPIE 生物系统和结构的健康监测 会议
2017/10/30
2018年SPIE生物系统和结构的健康监测会议（SPIE Health Monitoring of Structural and Biological Systems XII）。
This year, the Computational Structural Bioinformatics Workshop will be held in conjunction with ACM-BCB 2017. The rapid accumulation of macromolecular structures presents a unique set of challenges a...
由中国生物物理学会、清华大学、中科院生物物理研究所和FEI公司联合主办的第三次中国结构生物学冷冻电镜培训班定于2017年7月31日-8月5日在北京召开。
Structural biology has become one of the most important tools to understand the fundamental principles of life. Besides the commonly established X-ray crystallography and nuclear magnetic resonance (N...
We are pleased to announce the 2017 International Conference on Structural Biology on Biological Macromolecules: Structure, Catalysis and Regulation which will be held at the Tsinghua University, Beij...
Workshop 揈volutionary computation in computational structural biology?
Protein design computational biology
2016/7/19
In the last two decades, many computer scientists in Artificial Intelligence have made significant contributions to modeling biological systems as a means of understanding the molecular basis of mecha...
Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain
Humans Escherichia coli Benzamides Quinolines Nitriles Aniline Compounds Piperazines Pyrimidines Thiazoles Recombinant Proteins
2016/5/25
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein. The Abl inhibitors imatinib, nilotinib and dasatinib are currently used to treat CML, but resistance to t...
Ultrafast Excited-State Dynamics in the Green Fluorescent Protein Variant S65T/H148D.1.Mutagenesis and Structural Studies
Arabidopsis thaliana homogentisate phytyltransferase (HPT/VTE2) Lactuca sativa tocopherol tocopherol cyclase (TC/VTE1) vitamin e.
2016/5/24
Wild type green fluorescent protein (wt-GFP) and the variant S65T/H148D each exhibit two absorption bands, A and B, which are associated with the protonated and deprotonated chromophores, respectively...
Green Fluorescent Protein Variants as Ratiometric Dual Emission pH Sensors.1.Structural Characterization and Preliminary Application
Animals Cricetulus Cell Line Threonine Luminescent Proteins Green Fluorescent Proteins Microscopy, Confocal Crystallography, X-Ray Transfection Amino Acid Substitution
2016/5/24
Novel dual emission, pH-sensitive variants of the green fluorescent protein (GFP) have been constructed and are suitable for ratiometric emission measurements in vivo. This new class of GFPs, termed d...
19F NMR of Trifluoroacetyl-Labeled Cysteine Mutants of Myoglobin:Structural Probes of Nitric Oxide Bound to the H93G Cavity Mutant
19F NMR Trifluoroacetyl Cysteine Mutants Myoglobin Nitric Oxide H93G Cavity Mutant
2016/5/23
Nitric oxide (NO) binds to the myoglobin (Mb) cavity mutant, H93G, forming either a 5- or 6-coordinate Fe--NO heme complex. The H93G mutation replaces the proximal histidine of Mb with glycine, allowi...