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Generation of Fibroblasts Lacking the Sal-like 1 Gene by Using Transcription Activator-like Effector Nuclease-mediated Homologous Recombination
Transcription Activator-like Effector Nuclease [TALEN] Sal-like 1 Gene
2016/5/20
The Sal-like 1 gene (Sall1) is essential for kidney development, and mutations in this gene result in abnormalities in the kidneys. Mice lacking Sall1 show agenesis or severe dysgenesis of the kidneys...
Targeted Editing of Myostatin Gene in Sheep by Transcription Activator-like Effector Nucleases
Myostatin Targeted Gene Editing Sheep Primary Fibroblasts
2016/5/19
Myostatin (MSTN) is a secreted growth factor expressed in skeletal muscle and adipose tissue that negatively regulates skeletal muscle mass. Gene knockout of MSTN can result in increasing muscle mass ...