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O2 Activation and Allosteric Zn(Ii) Binding on Hif-Prolyl Hydroxylase-2 (Phd2)
N-terminal transactivation domain pVHL von-Hippel Lindau protein
2014/11/20
Oxygen homeostasis is essential to the life of aerobes, which is regulated in humans by Hypoxia Inducible Factor-1α (HIF-1α). Under hypoxic conditions, HIF-1α transactivates over a hundred genes relat...