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Extreme Electric Fields Power Catalysis in the Active Site of Ketosteroid Isomerase
Electric Power Catalysis Active Site Ketosteroid Isomerase
2016/5/25
Enzymes use protein architecture to impose specific electrostatic fields onto their bound substrates, but the magnitude and catalytic effect of these electric fields have proven difficult to quantify ...
Electrostatic Fields Near the Active Site of Human Aldose Reductase:2.New Inhibitors and Complications Caused by Hydrogen Bonds
Humans Nitriles Aldehyde Reductase Spectrophotometry, Infrared Spectroscopy, Fourier Transform Infrared Binding Sites Catalytic Domain Protein Binding Kinetics Hydrogen Bonding
2016/5/25
Vibrational Stark effect spectroscopy was used to measure electrostatic fields in the hydrophobic region of the active site of human aldose reductase (hALR2). A new nitrile-containing inhibitor was de...
Do Ligand Binding and Solvent Exclusion Alter the Electrostatic Character within the Oxyanion Hole of an Enzymatic Active Site
Pseudomonas putida Thiocyanates Anions Oxygen Steroid Isomerases Ligands Spectroscopy, Fourier Transform Infrared Kinetics Binding Sites Static Electricity
2016/5/24
The thousands of enzyme structures solved to date have consistently revealed that biological catalysis occurs within sequestered pockets containing complex interdigitations of polar and hydrophobic gr...
Electric Fields at the Active Site of an Enzyme:Direct Comparison of Experiment with Theory
Humans Nitriles Enzyme Inhibitors Spectrophotometry, Infrared Spectrum Analysis Circular Dichroism Electricity Protein Conformation Protein Structure,Tertiary Protein Folding
2016/5/24
The electric fields produced in folded proteins influence nearly every aspect of protein function. We present a vibrational spectroscopy technique that measures changes in electric field at a specific...
Dynamic clustering in active colloidal suspensions with chemical signaling
Dynamic cluster active colloidal suspensions chemical signaling
2012/2/29
In this paper, we explore experimentally the phase behavior of a dense active suspension of self- propelled colloids. In addition to a solid-like and a gas-like phase observed for high and low densiti...
Human olfactory receptor 17-40 as active part of a nanobiosensor: A microscopic investigation of its electrical properties
Human olfactory receptor microscopic investigation electrical properties
2011/8/17
Abstract: Increasing attention has been recently devoted to protein-based nanobiosensors. The main reason is the huge number of possible technological applications, going from drug detection to cancer...
Synthesis and properties of new optically active and organosoluble poly(ester-imide)s containing L-valine moieties in the main chain by direct polycondensation reaction
Poly(ester-imide)s direct polycondensation optically active polymers thermal properties
2011/4/6
New optically active poly(ester-imide)s (PEIs) containing bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetracarboxylic diimide in the main chain were prepared by the reaction of N,N'-(bicyclo[2,2,2]oct-7- ene-2,3,...
A simple and efficient procedure for synthesis of optically active 1,3,4-oxadiazole derivatives containing L-amino acid moieties
N-phetaloyl-L-amino acid 1,3,4-oxadiazole diacylhydrazide pyridoyl hydrazide
2010/10/19
Some new unsymmetrical and optically active 2,5-disubstituted 1,3,4-oxadiazoles 5a-j were efficiently synthesized by cyclization reaction of diacylhydrazides 4a-j. The synthesis of the title compounds...
Synthesis and characterization of new optically active polyamides containing 2-(4-nitro-1,3-dioxoisoindolin-2-yl)succinic acid and aromatic diamines via direct polycondensation
Optically active polymers polyamides (PAs , thermal stability
2010/10/14
A new class of optically active polyamides (PAs) (6a-e) having 4-nitro-1,3-dioxoisoindolin-2-yl pendent groups were prepared by direct polycondensation reaction of 2-(4-nitro-1,3-dioxoisoindolin-2-yl)...
Determination of Acid Dissociation Constants of Compounds Active at Neuronal Nicotinic Acetylcholine Receptors by Means of Electrophoretic and Potentiometric Techniques
Acid Dissociation Constants Compounds Active Neuronal Nicotinic Acetylcholine Receptors
2010/9/17
The dissociation constants of epiboxidine 2 and a series of bases active at neuronal nicotinic acetylcholine receptors were determined by means of potentiometric and electrophoretic methods, which gav...
Biologically Active Transition Metal Chelates with a 2-Thiophenecarboxaldehyde-Derived Schiff Base: Synthesis, Characterization, and Antibacterial Properties
Schiff base transition metal complex biological activity
2010/4/16
Metal complexes, ML2Cl2, where M is Fe(II), Co(II), Ni(II), Cu(II), Zn(II), or Cd(II), and L is the Schiff base formed by condensation of 2-thiophenecarboxaldehyde with 2-aminopyridine, N-(2-thienylme...
Efficient Synthesis of Imidazole Derivatives: An Important Synthon for the Preparation of Biologically Active Compounds
Imidazole N-chlorosuccinimide chloroimidazole chloroimidazole-carboxaldehyde
2010/4/16
4(5)-Chloro-imidazole-5(4)-carboxaldehyde derivatives are important precursors for the preparation of biologically active compounds. We developed a simple, novel, and efficient method for the synthesi...
Highly Selective Molecular Recognition of Biologically Active Substances Using Liquid Phase Separation
protein-conjugated chiral stationary phase affinity capillary lectrophoresis chiral discrimination acyl glucuornide acyl adenylate bile acid protein-bound adduct
2007/12/13
The development of new chiral stationary phases has been very important in the accurate analysis of drug enantiomers and their metabolites in biological samples during drug discovery and development. ...
专著信息
书名
Synthesis, Structures and Electrochemical Properties of Nitro- and Amino-Functionalized Diiron Azadithiolates as Active Site Models of Fe-Only Hydrogenases
语种
英文
撰写或编译
作者
Tianbiao Liu,Mei Wang...
专著信息
书名
Synthesis,structures and electrochemical properties of nitro-and amino-functionalized diron azadithiolates as active site models of Fe-only Hydrogenases,
语种
英文
撰写或编译
作者
T. Liu,M. Wang,Z. Shi,H...
