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Development of Mass Spectrometry-Based Methods for Quantitation and Characterization of Protein Drugs: Transferrin as a Model Drug Delivery Vehicle
Mass Spectrometry O18 labeling Protein quantitation Transferrin
2014/11/20
In the last two decades, protein drugs have enjoyed a rapid growth and achieved a tremendous success in treating human diseases. However, the presence of physiological barriers greatly impedes the eff...
Polarographic determination of anticancer drug vitamin K3 with direct and indirect methods/application to serum and K3 injection solution
Vitamin K3 sulfite direct indirect differential pulse polarography
2011/4/6
In this work, direct and indirect methods for determination of vitamin K3 were developed using differential pulse polarography. The reaction between sulfite and the quinone (Q) form of vitamin K3 was ...
Preparation and characterization of anticancer drug-loaded implantable PLGA microparticles
characterization Preparation anticancer drug-loaded implantable
2010/10/18
This article describes the preparation and characterization of anticancer drug-loaded poly(lactide-co-glycolide) (PLGA) microparticles. PLGA microparticles loaded with doxorubicin HCl (DOX) were prepa...
Development of Signaling Echo Method for Cell-based Quantitative Efficacy Evaluation of Anti-cancer Drugs in Apoptosis without Drug Presence Using High-precision Surface Plasmon Resonance Sensing
Signaling Echo Method Cell-based Quantitative Efficacy Evaluation Anti-cancer Drugs
2010/9/20
We propose a rapid and label-free quantitative evaluation of anti-cancer drug efficacy in apoptosis using live cancer cells cultured on a sensor chip. The resultant custom-made, high-precision surface...
Supramolecular Self-Assembling Cyanine as an Alternative to Ethidium Bromide Displacement in DNA–Drug Model Interactions during High Throughput Screening
Supramolecular Self-Assembling Cyanine Ethidium Bromide Displacement DNA–Drug Model
2010/9/17
Supramolecular self-assembling cyanine and spermine binding to genomic DNA was a model for DNA–drug interactions during high throughput screening. Spermine competitively inhibited the self-assembly of...
A Multidisciplinary Investigation to Determine the Structure and Source of Dimeric Impurities in AMG 517 Drug Substance
International Conference on Harmonization mass spectrometry multiple-quantum correlation
2009/9/4
In the initial scale-up batches of the experimental drug substance AMG 517, a pair of unexpected impurities was observed by HPLC. Analysis of data from initial LC-MS experiments indicated the presence...
Evaluation of Drug Interaction in Binding to Protein by High Performance Liquid Chromatography
high performance liquid chromatography frontal analysis chemiluminescence detection oxacillin cefoperazone human serum albumin drug interaction protein binding
2007/12/13
Evaluation of Drug Interaction in Binding to Protein by High Performance Liquid Chromatography。
专著信息
书名
A flow-injection ultrafiltration sampling chemiluminescence system for on-line determination of drug-protein interaction.
语种
英文
撰写或编译
作者
Zhouping Wang,Zhujun Zhang,Zhifeng Fu
第一作者单位
出版社
Anal B...
Synthesis and Antimicrobial Activities of Some New Flavonyl Pro-drug Esters of Ampicillin
Flavone derivatives Ampicillin Pro-drug ester Antimicrobial activities
2010/4/20
A new series of flavonyl pro-drug esters of ampicillin (Va-b) was prepared by condensing the appropriate bromomethyl flavone with ampicillin trihydrate potassium salt. Flavone derivatives and ampicill...
Cerimetric Determination of Propranolol in Bulk Drug Form and in Tablets
Propranolol titrimetry spectrophotometry cerium(IV) sulphate iron(III) thiocyanate
2010/4/21
Two simple, accurate and precise methods are described for the determination of propranolol hydrochloride with cerium(IV) sulphate. The titrimetric method is based on the oxidation of the drug by a kn...
Voltammetry of the Anticancer Drug Mitoxantrone and DNA
Mitoxantrone Biosensors DNA Voltammetry Intercalation
2010/4/22
The interaction of mitoxantrone (MTX) with calf thymus double-stranded DNA (dsDNA) and calf thymus single-stranded DNA (ssDNA) was studied electrochemically by using differential pulse voltammetry (DP...
Photochemically-Induced Fluorescence Properties and Determination of Flufenamic Acid, a Non-Steroidal Anti-Inflammatory Drug, in Urine and Pharmaceutical Preparation
Photochemically-induced fluorescence flufenamic acid urine analysis pharmaceutical preparation
2010/6/27
The photochemically-induced fluorescence (PIF) properties of flufenamic acid (FF), a non-steroidal anti-inflammatory drug (NSAID) were investigated in acidic (pH 1.0) aqueous solutions at room tempera...
