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The importance of distinct modeling strategies for gene and gene-specific treatment effects in hierarchical models for microarray data
Diffierential expression EM algorithm hierarchical models random effects uncertainty
2012/11/23
When analyzing microarray data, hierarchical models are often used to share information across genes when estimating means and variances or identifying differential expression. Many methods utilize so...
Detecting mutations in mixed sample sequencing data using empirical Bayes
Detecting mutations mixed sample sequencing data empirical Bayes
2012/11/23
We develop statistically based methods to detect single nucleotide DNA mutations in next generation sequencing data. Sequencing generates counts of the number of times each base was observed at hundre...
Correlations between Google search data and Mortality Rates
Correlations；Google search data Mortality Rates
2012/11/22
Inspired by correlations recently discovered between Google search data and financial markets, we show correlations between Google search data mortality rates. Words with negative connotations may pro...