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Changes in the mutual orientation of tRNA and 23S rRNA at the peptidyl transferase center of the ribosome detected by crosslinking of a photoreactive transition-state analog
Amino acids dynamic interaction ribosomes peptide bonds peptidyl transferase ribosomes
2014/12/11
Dynamic interactions between the amino acid acceptor end of tRNA and the ribosome underlie the synthesis of successive peptide bonds at the peptidyl transferase center (PTC) of the 50S ribosomal subun...
Probing the Peptidyl Transferase Center of Ribosomes Containing Mutant 23S rRNA with Photoreactive tRNA
ribosome peptidyl transferase center photoreactive crosslinking tRNA 23S rRNA translation
2014/12/9
There is strong crystallographic evidence that the 23S rRNA is the only catalytic entity in the peptidyl transferase center. Various mechanisms for the catalysis of peptidyl transfer have been propose...
