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Basal and FSH-stimulated steady state levels of SGP-2, alpha 2-macroglobulin, and testibumin in culture media of rat seminiferous tubules at defined stages of the epithelial cycle
Testis follicle-stimulating hormone SGP-2 a2-macroglobulin testibumin
2009/2/10
Production of several proteins by rat Sertoli cells is dependent on the stage of the cycle of the seminiferous epithelium. The authors have determined steady state levels and follicle-stimulating ...
The emerging role of alpha antagonists in the therapy of benign prostatic hyperplasia
Benign prostatic hyperplasia alpha blockade
2009/2/7
The rationale for using alpha blockade to treat benign prostatic hyperplasia (BPH) is based on the physiology and pharmacology of prostate smooth muscle. Approximately 20% of the area density of the...
4-MAPC, a 5 alpha-reductase inhibitor, reduces rat ventral prostate weight, DNA, and prostatein concentrations
4-MAPC, a 5 alpha-reductase inhibitor rat ventral prostate weight DNA prostatein concentrations
2009/2/7
Several compounds, such as 4-MAPC (4-methyl-3-oxo-4-aza-5 alpha-pregnane-20- carboxylate), that inhibit conversion of testosterone (T) to dihydrotestosterone (DHT) by 5 alpha-reductase have been demon...
Seminal alpha-glucosidase activity as a marker of epididymal pathology in nonazoospermic men consulting for infertility
human epididymis a-glucosidase epididymal markers clinical epididymal abnormalities functional epididymal failure
2009/2/6
Glucosidase (alpha G) activity was measured in sperm free seminal plasma from 1200 patients consulting for primary infertility, in whom clinical examination of epididymides revealed some abnormaliti...
Metabolism of 5 alpha reduced androgens by various tissues of the male rat
metabolism androgens glucuronides
2009/2/6
Since an animal model for the study of peripheral androgen metabolism is needed, we studied the metabolism of 5 alpha-reduced androgens in various tissues of the rat. Labeled DHT and 3 alpha androst...
Expression, action, and regulation of transforming growth factor alpha and epidermal growth factor receptor during embryonic and perinatal rat testis development
FSH gametogenesis mesenchymal-epithelial Sertoli
2008/12/29
The objective of the current study was to extend previous observations and examine the expression pattern and effects of transforming growth factor alpha (TGFalpha) and epidermal growth factor recep...
Immortalized testis cell lines from estrogen receptor（ER）alpha knock-out and wild-type mice expressing functional ERalpha or ERbeta
Immortalization HPV E6/E7 in vitro models
2008/12/29
The surprising findings that male mice lacking the estrogen receptor (ER) alpha (alphaERKO) have atrophic testis and are infertile proved that ERalpha is involved in normal testicular function. To o...
The effect of cardiac arrest on the blood-testis barrier to albumin, tumor necrosis factor-alpha, pituitary adenylate cyclase activating polypeptide, sucrose, and verapamil in the mouse
blood-testis albumin tumor necrosis factor-alpha pituitary adenylate cyclase
2008/12/26
Impotence commonly occurs after events such as acute myocardial infarction, coronary bypass, head trauma, and cerebral bleeding, including subarachnoid hemorrhage. We hypothesize that the hypoxia ac...
Morphologic changes in efferent ductules and epididymis in estrogen receptor-alpha knockout mice
Morphologic changes efferent ductules epididymis estrogen receptor-alpha
2008/12/25
Estrogen has been shown to have an important role in fluid reabsorption in efferent ductules of the testis. Our previous study of the estrogen receptor-alpha knockout mouse (ERKO) showed that the ...
Stromal Fibrosis Reaction in Rat Prostates Induced by Alpha 1 Adrenergic Stimulation
Phenylephrine prostatic intraepithelial neoplastic neoangiogenesis collagen prostate
2008/12/23
Most of the publications dealing with the experimental induction of prostatic neoplasia have focused on the description of epithelial lesions, but little attention has been paid to the involvement...
Stage- and Cell-Specific Expression of Soluble Guanylyl Cyclase Alpha and Beta Subunits, cGMP-Dependent Protein Kinase I Alpha and Beta, and Cyclic Nucleotide-Gated Channel Subunit 1 in the Rat Testis
Cyclic guanosine monophosphate sGC PKG-I CNG-1
2008/12/23
Several studies suggest that nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) modulate testicular function. In this study, we examined the expression of cGMP-dependent protein kinase ...
Gene Expression in Prostate Cancer Cells Treated With the Dual 5 Alpha-Reductase Inhibitor Dutasteride
LNCaP gene-expression profiling REDUCE trial apoptosis
2008/12/22
We sought preclinical data on the cellular and molecular effects of dutasteride in androgen-responsive, human prostate cancer (PCa) cells to better understand the mechanisms of action of 5 alpha-red...