搜索结果: 106-120 共查到“医学 alpha”相关记录121条 . 查询时间(0.451 秒)
目的: 研究甲珠对肝纤维化大鼠alpha-肌动蛋白(alpha-SMA)和转化生长因子-beta1(TGF-beta1)表达影响, 并探讨其抗纤维化机制. 方法: 采用400 mL/L CCL4 sc, 制备肝纤维化模型并以高[2.0 g/(kg·d)], 中[1.0 g/(kg·d)], 低剂量[0.5 g/(kg·d)]甲珠干预, 测定各组肝功能、血清TGF-beta1, 免疫组织化学法检测肝...
Seminal alpha-glucosidase activity as a marker of epididymal pathology in nonazoospermic men consulting for infertility
human epididymis a-glucosidase epididymal markers clinical epididymal abnormalities functional epididymal failure
2009/2/6
Glucosidase (alpha G) activity was measured in sperm free seminal plasma from 1200 patients consulting for primary infertility, in whom clinical examination of epididymides revealed some abnormaliti...
Metabolism of 5 alpha reduced androgens by various tissues of the male rat
metabolism androgens glucuronides
2009/2/6
Since an animal model for the study of peripheral androgen metabolism is needed, we studied the metabolism of 5 alpha-reduced androgens in various tissues of the rat. Labeled DHT and 3 alpha androst...
Expression, action, and regulation of transforming growth factor alpha and epidermal growth factor receptor during embryonic and perinatal rat testis development
FSH gametogenesis mesenchymal-epithelial Sertoli
2008/12/29
The objective of the current study was to extend previous observations and examine the expression pattern and effects of transforming growth factor alpha (TGFalpha) and epidermal growth factor recep...
Immortalized testis cell lines from estrogen receptor（ER）alpha knock-out and wild-type mice expressing functional ERalpha or ERbeta
Immortalization HPV E6/E7 in vitro models
2008/12/29
The surprising findings that male mice lacking the estrogen receptor (ER) alpha (alphaERKO) have atrophic testis and are infertile proved that ERalpha is involved in normal testicular function. To o...
The effect of cardiac arrest on the blood-testis barrier to albumin, tumor necrosis factor-alpha, pituitary adenylate cyclase activating polypeptide, sucrose, and verapamil in the mouse
blood-testis albumin tumor necrosis factor-alpha pituitary adenylate cyclase
2008/12/26
Impotence commonly occurs after events such as acute myocardial infarction, coronary bypass, head trauma, and cerebral bleeding, including subarachnoid hemorrhage. We hypothesize that the hypoxia ac...
Morphologic changes in efferent ductules and epididymis in estrogen receptor-alpha knockout mice
Morphologic changes efferent ductules epididymis estrogen receptor-alpha
2008/12/25
Estrogen has been shown to have an important role in fluid reabsorption in efferent ductules of the testis. Our previous study of the estrogen receptor-alpha knockout mouse (ERKO) showed that the ...
Stromal Fibrosis Reaction in Rat Prostates Induced by Alpha 1 Adrenergic Stimulation
Phenylephrine prostatic intraepithelial neoplastic neoangiogenesis collagen prostate
2008/12/23
Most of the publications dealing with the experimental induction of prostatic neoplasia have focused on the description of epithelial lesions, but little attention has been paid to the involvement...
Stage- and Cell-Specific Expression of Soluble Guanylyl Cyclase Alpha and Beta Subunits, cGMP-Dependent Protein Kinase I Alpha and Beta, and Cyclic Nucleotide-Gated Channel Subunit 1 in the Rat Testis
Cyclic guanosine monophosphate sGC PKG-I CNG-1
2008/12/23
Several studies suggest that nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) modulate testicular function. In this study, we examined the expression of cGMP-dependent protein kinase ...
Gene Expression in Prostate Cancer Cells Treated With the Dual 5 Alpha-Reductase Inhibitor Dutasteride
LNCaP gene-expression profiling REDUCE trial apoptosis
2008/12/22
We sought preclinical data on the cellular and molecular effects of dutasteride in androgen-responsive, human prostate cancer (PCa) cells to better understand the mechanisms of action of 5 alpha-red...
靶向PKC-alpha mRNA的反义药物优化设计及相关药理学研究
反义 肿瘤 蛋白激酶
2008/11/28
以PKC-a为靶点，从靶mRNA的二级结构、反应自由能以及mRNA与产物蛋白的系统发育保守性几个方面综合考虑进行反义药物优化设计，分析构效关系，总结反义药物设计的规律。利用计算机模拟mRNA的空间结构并结合分子生物学和QSAR研究，在反义药物设计方法上有所创新,可以依据QSAR方程对反义药物药效进行预测；将系统发育比较分析引入反义药物设计的范畴，在反义药物设计方法上进行了有意义的新的探索；为反...
探讨alpha B-crystallin 基因在结肠癌组织中的表达及其与结肠癌临床病理的相关性。
THE INVESTIGATION OF CRITERION VALIDITY OF THE MODIFIED ASHWORTH SCALE USING THE ALPHA MOTONEURON EXCITABILITY INDICATORS
MAS Hoffmann Reflex
2010/4/20
The purpose of this study was to investigate the validity of the modified Ashworth Scale (MAS) by using both the conventional (Hmax/Mmax ratio) and the new indicators (Hslp/Mslp) of motoneuron excitab...
Effect of an increased intake of α-linolenic acid and group nutritional education on cardiovascular risk factors:the Mediterranean Alpha-linolenic Enriched Groningen Dietary Intervention (MARGARIN) study
α-Linolenic acid linoleic acid prevention ischemic heart disease nutritional education cardiovascular risk factors Netherlands MARGARIN study
2016/12/17
Background: The effect of long-term increased intakes of α-linolenic acid (ALA; 18:3n−3) on cardiovascular risk factors is unknown.Objectives: Our objectives were to assess the effect ...
Alpha-DHEC神经保护作用依赖核因子Kappa B的激活
α-二氢麦角隐亭 核因子kappa B 脑缺血 细胞凋亡
2010/1/14
目的 探讨α-二氢麦角隐亭(alpha-DHEC)的神经保护作用与核因子Kappa B(NF-κB)激活的相关性。方法 采用大鼠大脑中动脉闭塞诱导神经元凋亡，用迁移率改变法(EMSA)检测NF-κB活性，流式细胞仪(FCM)和TUNEL法检测神经元凋亡。结果 脑缺血1，3，6和12 h均伴有NF-κB激活，其中以缺血3 h尤为显著。100 μg.kg-1和150 μg.kg-1的alpha-DHE...