搜索结果: 91-105 共查到“医学 alpha”相关记录121条 . 查询时间(0.129 秒)
Appearance of alpha-smooth muscle actin in peritubular cells of monkey testes is induced by androgens, modulated by follicle-stimulating hormone, and maintained after hormonal withdrawal
alpha-smooth muscle actin peritubular cells androgens follicle-stimulating hormone
2009/2/12
This study analyzed the hormonal requirements necessary for the development of primate testicular peritubular cells. Alpha-smooth muscle actin, as a specific differentiation marker for peritubular c...
Insulin-like growth factor 1, but not growth hormone, has in vitro proliferative effects on neonatal foreskin fibroblasts without affecting 5-alpha-reductase or androgen receptor activity
5-a-Reductase androgen receptor micropenis
2009/2/11
Clinical observation of patients with congenital growth hormone (GH) deficiency and Laron-type dwarfism suggests that factors such as GH or insulin-like growth factor 1 (IGF-1) might in addition to ...
Human interleukin-1 alpha crosses the blood-testis barriers of the mouse
Cytokine Sertoli cell transport blood-brain barrier germinal cells
2009/2/10
Interleukin-1 alpha (IL-1 alpha) has been shown to have direct effects on the gonads, affecting steroidal secretion, DNA synthesis by spermatogonia, and the immune function of the testes. It is un...
The lack of effect of tumor necrosis factor-alpha, interleukin-1-alpha, and interferon-gamma on human sperm motility in vitro
Tumor necrosis factor interleukin-1 interferon human sperm motility
2009/2/10
Whether cytokines present in human peritoneal fluid reduce sperm motility, and thus contribute to infertility, is investigated. The human recombinant cytokines, tumor necrosis factor-alpha, interl...
Basal and FSH-stimulated steady state levels of SGP-2, alpha 2-macroglobulin, and testibumin in culture media of rat seminiferous tubules at defined stages of the epithelial cycle
Testis follicle-stimulating hormone SGP-2 a2-macroglobulin testibumin
2009/2/10
Production of several proteins by rat Sertoli cells is dependent on the stage of the cycle of the seminiferous epithelium. The authors have determined steady state levels and follicle-stimulating ...
目的: 探讨TNF-alpha、TGF-beta1、hs-CRP在非酒精性脂肪性肝病患者中的表达及临床意义. 方法: 选择武汉市第三医院消化内科单纯性脂肪肝51例, 非酒精性脂肪性肝炎48例及健康对照者32例, 测定血清hs-CRP水平, 采用酶联免疫吸附实验(ELISA)测定血清中TNF-alpha、TGF-beta1水平. 结果: TNF-alpha、TGF-beta1及hs-CRP是非酒精性...
RNA干扰介导的IkappaB蛋白激酶alpha及gamma基因沉默对巨噬细胞分泌细胞因子的影响
基因沉默 RNA干扰 核因子-κB IκB激酶 脂多糖 诱生性一氧化氮合酶 肿瘤坏死因子-α 白介素-10 巨噬细胞
2009/2/9
目的: 探讨IkappaB蛋白激酶alpha及gamma基因沉默对巨噬细胞分泌的NF-kappaB依赖性的下游炎性因子表达的影响. 方法: 应用RNA干扰技术将IkappaB蛋白激酶alpha及gamma基因沉默后, 观察RAW264.7小鼠巨噬细胞经LPS刺激后, NF-kappaB的活化以及多种NF-kappaB依赖性的下游炎性因子的表达. 结果: RNA干扰处理后RAW264.7巨噬细胞中I...
目的: 研究拟胆碱药卡巴胆碱对烫伤大鼠口服补液时小肠TNF-alpha及水通道蛋白-1(AQP-1)表达的影响. 方法: ♂Wistar大鼠50只, 随机分为假烫(N)、单纯烫伤(S)、肠内葡萄糖-电解质液(GES)、肠内卡巴胆碱组(CAR)和肠内葡萄糖-电解质液+卡巴胆碱组(GES/CAR)5组(n = 10). 大鼠背部用沸水造成35% TBSA烫伤. N, GES和GES/CAR组于伤后30...
目的: 研究重症急性胰腺炎(SAP)大鼠细胞凋亡、Caspase-3表达及其与疾病严重程度的关系. 方法: 40只SD大鼠随机分成对照组(SAP组, 胆管逆行性注射牛磺胆酸钠制备SAP模型, n = 20), 实验组(干预组, SAP模型制作成功后, 注射重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白, n = 20). 测定两组血清淀粉酶和TNF-alpha含量, 采用免疫组化法分析Caspase-3...
目的: 探讨核因子-kappaB(nuclear factor-kappa B, NF-kappaB)及其下游因子TNF-alpha、Bcl-2在急性肝损伤的作用及机制. 方法: ♂Wistar大鼠90只随机分为正常组, 硫代乙酰胺(TAA)造模组及脯氨酸二硫代氨基甲酸酯(PDTC)预处理组(n = 30). 三组大鼠分别于造模完成后6、24、48 h 3个时间点处死, 每个时间点各取10只大鼠....
目的: 探讨中医不同证型患者的慢性胃病变组织中TGF-alpha和Cyclin E表达的变化, 并分析两者表达的相关性. 方法: 慢性胃病患者(慢性良性胃病变和胃癌)135例, 按中医分为肝胃不和、脾胃虚寒、胃阴不足和寒热夹杂4种证型. 对患者慢性胃病变组织进行TGF-alpha和Cyclin E表达的免疫组化染色, 对两者在各中医证型中表达的阳性率进行比较, 并进一步分析TGF-alpha和Cy...
The emerging role of alpha antagonists in the therapy of benign prostatic hyperplasia
Benign prostatic hyperplasia alpha blockade
2009/2/7
The rationale for using alpha blockade to treat benign prostatic hyperplasia (BPH) is based on the physiology and pharmacology of prostate smooth muscle. Approximately 20% of the area density of the...
4-MAPC, a 5 alpha-reductase inhibitor, reduces rat ventral prostate weight, DNA, and prostatein concentrations
4-MAPC, a 5 alpha-reductase inhibitor rat ventral prostate weight DNA prostatein concentrations
2009/2/7
Several compounds, such as 4-MAPC (4-methyl-3-oxo-4-aza-5 alpha-pregnane-20- carboxylate), that inhibit conversion of testosterone (T) to dihydrotestosterone (DHT) by 5 alpha-reductase have been demon...
乙型肝炎病毒全S蛋白与纤维蛋白原alpha链的相互作用
乙型肝炎病毒 全S基因 纤维蛋白原α链
2009/2/7
目的: 筛选人肝细胞cDNA文库中与乙型肝炎病毒(HBV)全S蛋白相互作用蛋白的基因, 并反向验证HBV全S蛋白候选结合蛋白之间相互作用. 方法: 将全S基因定向克隆到酵母表达载体pDEST 32, 构建正向筛选的诱饵质粒并Western blot法验证其在酵母中的表达. 将诱饵质粒与人肝细胞cDNA文库质粒共同转化MaV203酵母细胞, 在人肝细胞cDNA文库筛选候选结合蛋白, 提取阳性菌落质粒...
目的: 探讨茶多酚对酒精性肝病大鼠TNF-alpha表达及肝细胞病变的影响. 方法: 29只大鼠随机分为: 对照组、模型组、茶多酚干预组. 白酒ig建模, 茶多酚干预. 常规切片及特染评价肝组织病变, 检测血清AST、ALT、MDA含量, ELISA法检测血清TNF-alpha、RT-PCR检测肝组织TNF-alpha mRNA表达. 结果: 与模型组相比, 茶多酚干预组大鼠肝组织学评分(3.00...