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The loss of alpha-adrenergic effect during the erectile response in the long-term diabetic rat
Diabetic rats erectile response nitroglycerin phenylephrine
2009/2/17
The present study was designed to investigate the effect of long-term, streptozotocin-induced diabetes on the erectile response in the laboratory rat. Mean arterial blood pressure (MAP) and intracav...
Sperm motion predicts fertility in male hamsters treated with alpha-chlorohydrin
Sperm motion predicts fertility male hamsters alpha-chlorohydrin
2009/2/17
An understanding of the relationship between altered sperm motion and sperm function (fertility) is important when interpreting the biological significance of toxicant-induced changes in sperm veloc...
Estrogen receptor（alpha and beta）expression in the excurrent ducts of the adult male rat reproductive tract
Efferent ductules immunohistochemistry
2009/2/17
The understanding of estrogen's function in the male reproductive tract is limited, and estrogen receptor (ER) localization in the reproductive tract of the adult male rat has not been described. ...
Differential methylation in steroid 5 alpha-reductase isozyme genes in epididymis, testis, and liver of the adult rat
Gene methylation gene expression androgens dihydrotestosterone eukaryotic adenine methylation
2009/2/17
DNA methylation has been largely involved in the regulation of tissue-specific gene expression. The aim of the study was to determine the methylation pattern of steroid 5 alpha-reductase genes 1 and 2...
Pharmacokinetics of 7 alpha-methyl-19-nortestosterone in men and cynomolgus monkeys
MCR SHBG replacement therapy male
2009/2/17
Testosterone and its esters are widely used for androgen replacement therapy. In the prostate, testosterone ins 5 alpha-reduced to dihydrotestosterone (DHT), which leads to an amplification of its...
Effects of a 5 alpha-reductase inhibitor, finasteride, on the developing prostate and testis of a marsupial
Virilization Wolifian duct tammar wallaby androgen dihydrotestosterone
2009/2/17
This study examines the role of dihydrotestosterone in virilization of the developing male tammar. The onset of prostate differentiation in this marsupial species normally occurs around 25 days po...
Androgens modulate the alpha-adrenergic responsiveness of vascular smooth muscle in the corpus cavernosum
Penile erection testosterone adrenergic prazosin
2009/2/17
Rat penile erection is an androgen-dependent process with castration leading to a loss of potency. The present study was designed to determine if one of the mechanisms by which androgens maintain th...
Testosterone autoregulation of its biosynthesis in the rat testis：inhibition of 17 alpha-hydroxylase activity
1 7a-Hydroxylase testosterone autoregulation rat
2009/2/16
Using the in vitro perfused rat testis, the effects of testosterone (T) on its own biosynthesis, and in particular on the inhibition of specific steroidogenic step(s) in the biosynthetic pathway fro...
The mRNAs for the steroid 5 alpha-reductase isozymes, types 1 and 2, are differentially regulated in the rat epididymis
Androgens development hormonal regulation male
2009/2/16
The enzyme steroid 5 alpha-reductase (EC 1.3.1.22) catalyzes the conversion of testosterone to its more potent form, dihydrotestosterone (DHT), in many androgen-sensitive target tissues. In the ep...
Synchronous assessment of sperm motility and fertilizing ability in the hamster following treatment with alpha-chlorohydrin
Synchronous assessment sperm motility fertilizing ability
2009/2/13
To investigate the relationship between sperm motion parameters and fertilizing ability, a model was developed to assess both of these endpoints synchronously using a toxicant that inhibits sperm mo...
Effect of TGF-beta 1, TGF-alpha, and EGF on cell proliferation and cell death in rat ventral prostatic epithelial cells in culture
Prostate epithelium TGF-91 TGF-a EGF apoptosis
2009/2/13
A tissue culture system for rat prostatic epithelial cells was developed, and the effect of epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and transforming growth facto...
The immunohistochemical localization of alpha 2-macroglobulin in rat testes is consistent with its role in germ cell movement and spermiation
immunohistochemical localization alpha 2-macroglobulin rat testes
2009/2/13
alpha 2-Macroglobulin (alpha 2-MG) is a nonspecific protease inhibitor and binding protein for peptide hormones that was recently isolated from Sertoli cell-enriched culture medium and shown to be t...
Significant role of 5 alpha-reductase on feedback effects of androgen in rat anterior pituitary cells demonstrated with a nonsteroidal 5 alpha-reductase inhibitor ONO-3805
Significant role 5 alpha-reductase androgen rat anterior pituitary cells
2009/2/12
A 5 alpha-reductase inhibitor with nonsteroidal structure, ONO-3805, has been used to study the role of 5 alpha-reductase on positive and negative feedback effects of androgen on gonadotropin secret...
Acute immobilization stress disrupts testicular steroidogenesis in adult male rats by inhibiting the activities of 17 alpha-hydroxylase and 17,20-lyase without affecting the binding of LH/hCG receptors
Stress rats testosterone 17a-hydroxylase
2009/2/12
We have investigated the effect of acute immobilization (3 hours) stress on testicular steroidogenesis in the adult rat. Immobilization did not alter plasma luteizing hormone (LH) levels, but plas...
Human osteoblast-like cells contain specific, saturable, high-affinity glucocorticoid, androgen, estrogen, and 1 alpha,25-dihydroxycholecalciferol receptors
Human osteoblast-like cells glucocorticoid receptors androgen receptor estrogen receptor
2009/2/12
Glucocorticoids, androgens, estrogens and 1 alpha,25-dihydroxycholecalciferol (1 alpha,25-(OH)2D3) exert a variety of effects on bone homeostasis. We have measured the receptors for these hormones...