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Step-growth thiol-ene photopolymerization to form degradable, cytocompatible and multi-structural hydrogels
hydrogel biomaterial degradation multi-structure photopolymerization thiol-ene chemistry
2015/1/12
Hydrogels prepared from photopolymerization have been used for a variety of tissue engineering and controlled release applications. Polymeric biomaterials with high cytocompatibility, versatile degrad...
Mechanical property and biocompatibility of PLLA coated DCPD composite scaffolds
biomedical engineering scaffolds biomaterial tissue engineering
2015/1/12
Dicalcium phosphate dihydrate (DCPD) cements have been used for bone repair due to its excellent biocompatibility and resorbability. However, DCPD cements are typically weak and brittle. To overcome t...
Multi-scale analysis of morphology, mechanics, and composition of collagen in murine osteogenesis imperfecta
Atomic force microscopy Raman spectroscopy Reference point indentation MicroCT crystallinity modulus
2015/1/12
Osteogenesis imperfecta is a rare congenital disease commonly characterized by brittle bones caused by mutations in the genes encoding Type I collagen, the single most abundant protein produced by the...
A NOVEL FURANONE-CONTAINING ANTIBACTERIAL SYSTEM FOR IMPROVED DENTAL RESTORATIVES
dental material antibacterial
2015/1/12
The furanone derivatives and their constructed polymers were synthesized, characterized and formulated into dental glass-ionomer cement (GIC) and resin composite for improved antibacterial properties....
PREPARATION AND EVALUATION OF NOVEL ANTIBACTERIAL DENTAL RESIN COMPOSITES
DENTAL MATERIAL FURANONE QUARTERNARY AMMONIUM SALT ANTIBACTERIAL
2015/1/12
Both quaternary ammonium bromide (QAB) and furanone derivatives were synthesized, characterized and formulated into dental resin composites for improved antibacterial properties. Compressive strength ...
Preparation and Evaluation of Antibacterial Dental Glass-ionomer Cements
antibacterial glass-ionomer cement
2015/1/12
The functional quaternary ammonium salts (QAS) and their constructed polyQAS or PQAS were synthesized, characterized and formulated into a novel antibacterial glass-ionomer cement. Compressive strengt...
Tissuemechanical properties reflect extracellular matrix composition and organization, and as such, their changes can be a signature of disease. Examples of such diseases include intervertebral disk d...
Distribution of Type I Collagen Morphologies in Bone: Relation to Estrogen Depletion
AFM Ultrastructure disease diagnosis
2014/11/6
Bone is an amazing material evolved by nature to elegantly balance structural and metabolic needs in the body. Bone health is an integral part of overall health, but our lack of understanding of the u...
Inbred Strain-Specific Effects of Exercise in Wild Type and Biglycan Deficient Mice
Transgenic Mechanical properties Exercise Micro CT Raman
2014/11/6
Biglycan (bgn)-deficient mice (KO) have defective osteoblasts which lead to changes in the amount and quality of bone. Altered tissue strength in C57BL6/129 (B6;129) KO mice, a property which is indep...
Type I Collagen Exists as a Distribution of Nanoscale Morphologies in Teeth, Bones and Tendons
collagen nanoscale morphologies bones
2014/11/6
This study demonstrates that collagen, the most abundant protein in animals, exists as a distribution of nanoscale morphologies in teeth, bones, and tendons. This fundamental characteristic of Type I ...
Cortical Bone Mechanical Properties Are Altered in an Animal Model of Progressive Chronic Kidney Disease
chronic kidney disease whole bone mechanical properties
2014/11/6
Chronic kidney disease (CKD), which leads tocortical bone loss and increasedporosity,increases therisk of fracture. Animal models have confirmed that these changes compromise whole bone mechanical pro...
Physical Weight Loading Induces Expression of Tryptophan Hydroxylase 2 in the Brain Stem
mechanical loading serotonin
2014/11/6
Sustaining brain serotonin is essential in mental health. Physical activities can attenuate mental problems by enhancing serotonin signaling. However, such activity is not always possible in disabled ...
Multi-scale Analysis of Bone Chemistry, Morphology and Mechanics in the oim Model of Osteogenesis Imperfecta
Atomic force microscopy Raman Spectroscopy Reference Point Indentation MicroCT Crystallinity Modulus
2014/11/6
Osteogenesis imperfecta is a congenital disease commonly characterized by brittle bones and caused by mutations in the genes encoding Type I collagen, the single most abundant protein produced by the ...
Multiscale analysis of morphology and mechanics in tail tendon from the ZDSD rat model of type 2 diabetes
AFM Tension Nanoscale Ultrastructure Modulus
2014/11/6
Type 2 diabetes (T2D) impacts multiple organ systems including the circulatory, renal, nervous and musculoskeletal systems. In collagen-based tissues, one mechanism that may be responsible for detrime...