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Background: Maternal cigarette smoking causes health risks and developmental defects in the offspring. So far, many studies have been conducted to suppress the effects of nicotine. However, the effect...
Context: The aim of this review study was to evaluate therapeutic mild hypothermia, its complications and various methods for induced mild hypothermia in patients following resuscitation after out-of-...
Background: Myocardial infarction is one of the important causes of death during old ages. Gallic acid as an antioxidant or cyclosporine A (CsA) as inhibitor of mitochondrial permeability transition p...
Background: Endotheline-1 (ET-1), an endothelial mediator, influences on mineral metabolism; especially vascular calcification in uremic patients.
Background: Hypertension is considered as a major public health problem in most countries due to its association with ischemic heart disease which causes cerebrovascular disease and death.
Background: Matrix metalloproteinases (MMPs) are a group of endopeptidases which comprised of various types. These proteolytic enzymes are zinc-dependent and play role in degradation of extracellular ...
Background:: Ischemic heart disease is the leading cause of death in most societies. In a pathophysiologic point of view, it chiefly results from the formation of thrombus in coronary arteries which c...
Background:: Anti-inflammatory effect of natural adjuvants has been reported. Lung inflammation is the most characterized pathological feature in asthma.
Background:: Sequence variations in glycoproteins of influenza virus surface impel us to design new candidate vaccines yearly. Ectodomain of influenza M2 protein is a surface and highly conserved prot...
Background:: In diabetes mellitus because of the absence or insufficient sensitivity to insulin, glucose transporter protein in cell membrane, glucose transporter 4, is decreased. GLUT4 is the major g...
Introduction:: Haemophilia A is the most common inherited X-linked recessive bleeding disorder. The severity of the resultant bleeding diathesis depends on the FVIII levels associated with the mutatio...
Background:: Scorpion venom is important and rich source of peptides, most of which have been widely used as pharmacological tools for unraveling structure-function relationship of various ion channel...
比较Lipofectamine2000、lipoplexes和apoE-lipoplexes三种脂质体对Li-7肝癌细胞的转染效率。方法 构建普通阳离子脂质体lipoplexes和载脂蛋白apoE修饰脂质体apoE-lipoplexes;使用Lipofectamine2000,lipoplexes和apoE-lipoplexes三种脂质体运载以EGFP为报告基因的pGenesil-1质粒转染Li-...
提高mCherry红色荧光蛋白(red fluorescence protein,RFP)在结肠癌细胞中的表达,从而可以通过检测共培养体系中细胞的荧光值来分析结肠癌细胞的增殖,以利于结肠癌肿瘤微环境的研究。方法 用293FT细胞制备pBMN-mCherry病毒液。利用多次感染(1~4次)的方法提高RFP在结肠癌细胞系HT29、LoVo、SW620及HCT116中的表达,经流式细胞仪检测得到不同感...
分析大肠癌始动细胞群锌指蛋白表达谱变化信息。 方法 采用无血清悬浮培养结合CD133抗体标记磁珠分选获得Colo205来源大肠癌始动细胞,高通量测序分析180个锌指蛋白基因mRNA表达谱变化,并筛选差异表达基因,利用荧光定量PCR技术对部分差异表达基因进行表达变化验证。 结果 与CD133-细胞群相比,CD133+细胞群有56个锌指蛋白基因表达下调,42个锌...

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