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The Human Genome Project was an ambitious initiative to sequence every piece of human DNA. The project drew together collaborators from research institutions around the world, including MIT's Whitehea...
Last year, researchers at MIT’s McGovern Institute for Brain Research discovered and characterized Cas7-11, the first CRISPR enzyme capable of making precise, guided cuts to strands of RNA without har...
以作物矮化育种为标志的“绿色革命”使世界作物产量大幅度提高。但矮秆品种一般存在氮肥利用效率降低的缺点，其产量对化肥投入的依赖性很高。过高的氮肥投入不仅增加种植成本，还会造成环境污染。如何突破作物高产和氮高效协同改良的育种瓶颈，实现在减少氮肥投入的前提下提高作物产量，已成为当前农业可持续发展亟待解决的重大问题。
线粒体中实现A到G碱基转换 基因编辑技术，最后一块拼图补齐
线粒体 碱基转换 细胞 基因编辑
2022/5/10
韩国基础科学研究所（IBS）基因组工程中心研究人员开发了一种新的基因编辑平台，称为类转录激活因子效应相关脱氨酶（TALED）。TALED是能够在线粒体中进行A到G碱基转换的碱基编辑器。这一发现是长达数十年治愈人类遗传疾病之旅的结晶，而TALED，也被认为是基因编辑技术中最后缺失的一块拼图。研究成果发表在最新一期《细胞》杂志上。
In human chromosomes, DNA is coated by proteins to form an exceedingly long beaded string. This “string” is folded into numerous loops, which are believed to help cells control gene expression and fac...
Despite the sheer number of genes that each human cell contains, these so-called “coding” DNA sequences comprise just 1 percent of our entire genome. The remaining 99 percent is made up of “non-coding...
Ateam of researchers led by Harvard and Broad Institute scientists has developed twin prime editing, a new, CRISPR-based gene-editing strategy that enables manipulation of gene-sized chunks of DNA in ...
Cut off the head of a three-banded panther worm, and it will grow another — mouth, brain, and all. Cut off its tail, and the same thing happens. Cut it in three pieces, and within eight weeks there’ll...
When Sharif Tabebordbar was a teenager, his father began having trouble walking. Soon, he became wheelchair-bound and was diagnosed with a rare genetic muscle disease.
The cost of DNA sequencing has plummeted at a rate faster than Moore’s Law, opening large markets in the sequencing space. Genomics for cancer care alone is predicted to hit $23 billion by 2025, but s...
Researchers at MIT’s McGovern Institute for Brain Research have discovered a bacterial enzyme that they say could expand scientists’ CRISPR toolkit, making it easy to cut and edit RNA with the kind of...
New gene-editing technique shows promise against sickle cell disease（图）
镰状细胞性贫血 基因编辑技术 一次性治疗
2023/6/21
Ateam of researchers led by scientists from Harvard and the Broad Institute used a new gene-editing technique to successfully treat sickle cell disease in mice. This advancement could one day lead to ...
Elizabeth Kellogg, assistant professor of molecular biology and genetics in the College of Arts and Sciences, has been named to the Pew Scholars Program to pursue research into advancing gene editing ...
Gene editing, or purposefully changing a gene’s DNA sequence, is a powerful tool for studying how mutations cause disease, and for making changes in an individual’s DNA for therapeutic purposes. A nov...
世界首批克隆缉毒犬韩国上岗（图）
世界首批 克隆缉毒犬 韩国
2009/7/22
据英国广播公司报道，韩国海关已在主要机场和边界部署“世界上第一批克隆缉毒犬”。这6只缉毒警犬2007年克隆自一只加拿大缉毒犬，它们在完成16个月的训练后顺利上岗。