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Misoprostol and the Sildenafil analog (PHAR-0099048) Modulate Cellular Efflux of cAMP and cGMP Differently
ABC-Transporters cAMP cGMP Misoprostol Sildenafil
2013/2/19
In the present study we have characterized ATP-dependent transport of cAMP and cGMP in physiological, but also supraphysiological concentrations. The uptake into inside-out vesicles from human erythro...
Sildenafil Inhibits the Proliferation of Cultured Human Endothelial Cells
atherosclerosis basic fibroblast growth factor endothelial proliferation plaque angiogenesis
2009/4/20
The proliferation of endothelial cells plays a crucial role in the development of intraplaque angiogenesis (IPA). IPA is a major source of intraplaque hemorrhage and therefore contributes to the desta...