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Brain stimulation in rats exposed to hyperbaric environments
hyperbaric environments Brain pressures
2009/7/20
Six rats were trained to make an operant response to receive brief trains of electrical current to the lateral hypothalamus (self-stimulation). All animals were then randomly exposed to pressures of 4...
Blood-brain and blood-lung barrier alteration by dysbaric exposure
decompression blood-lung exposure
2009/7/20
Failure of certain circulating substances to penetrate specific organs led to the concept of blood-organ barriers. Such barriers can be altered by various physical or chemical means. This report conce...
Decompression sickness in the goat:nature of brain and spinal cord lesions at 48 hours
decompression animal goat
2009/7/17
An investigation was undertaken to determine whether permanent damage to the central nervous system (CNS) is associated with transient decompression sickness in the goat. Twelve goats were compressed ...
Increased blood-brain barrier permeability to tetracycline in rabbits under dysbaric conditions
decompression tetracycline permeability rabbits
2009/7/17
Alteration of the blood-brain barrier (BBB) by dysbaric exposure may have relevance in several areas of hyperbaric medicine. Drugs administered to persons exposed to dysbaric conditions, e.g., divers,...
Correspondence of brain and rectal temperatures of guinea pigs in helium environments
helium-oxygen environment thermal animal guinea pig
2009/7/16
Brain and rectal temperatures were measured in guinea pigs exposed to helium-oxygen environments at pressures as high as 50 bars. Very high correlations (r = .856, P less than 0.001) between the two v...
Changes in blood-brain barrier permeability to drugs in decompressed rats
decompression human blood brain barrier animal rat drug
2009/7/16
A study has been made of changes in permeability of the blood-brain barrier (BBB) to drugs following exposure to compression-decompression. Fifty-five rats were exposed to 6.1 b (abs) air for 90 min a...
Effects of hyperbaric oxygen on heart,brain,and lung functions in rat
hyperbaric rat heart brain lung oxygen pressures
2009/7/16
Electrocardiogram (ECG), electrocorticogram (ECoG), and respiratory rate (RR) were monitored in awake, unrestrained rats during continuous exposure to 1, 3, and 5 ATA O2 until death. The RR showed a c...
Effect of propranolol on brain electrical activity during hyperbaric oxygenation in the rat
drug brain electrical activity propranolol oxygen toxicity animal rat
2009/7/14
The effect of 1, 2, and 5 mg/kg propranolol on the neuroelectrophysiological manifestations of CNS oxygen toxicity was studied in conscious rats. Cortical electrodes for electrocorticographic (ECoG) r...
Effects of high pressure on the release of excitatory amino acids by brain synaptosomes
decompression neurological
2009/7/14
Excitatory amino acid antagonists have been shown to protect against the hyperexcitability associated with exposure to high pressure. This suggests that these excitatory neurotransmitter substances ma...
The effect of high pressure on the kinetics of monoamine transmitters in the rat brain
drug hyperbaric serotonin noradrenaline dopamine animal rat monoamine transmitter
2009/7/14
The effects of 71 ATA pressure on the turnover of serotonin (5-HT), noradrenaline (NA), and dopamine (DA) were studied. High pressure increased the concentration of the 5-HT metabolite 5-hydroxyindole...
Rat brain catecholamine release at 1,10,20,and 100 ATA heliox,nitrox,and trimix
helium heliox nitrogen narcosis animal rat nitrox chamber catecholamine
2009/7/10
The pattern of neurotransmitter release in the rat caudate and hypothalamus was studied following exposure to pressure in combination with various gas mixtures. The caudate was selected for its contro...
Microbubble damage to the blood-brain barrier: relevance to decompression sickness
decompression pulmonary blood brain barrier bubbles animal Guinea Pigs
2009/7/8
Decompression sickness affecting the nervous system is still a serious problem in diving, but the mechanisms involved are in dispute. Although microbubbles can be detected in the pulmonary artery on d...
Relationship between the event-related brain potential P300 and inert gas narcosis
narcosis cognitive inert gas narcosis
2009/6/12
It is known that inert gas narcosis slows both reaction time (RT) and the event-related brain potential P300 in a correlated and dose-dependent manner. On the assumption that P300 reflects the time to...
Failure of normobaric oxygen therapy to reduce ischemic brain damage in rats
outcomes ischemic brain damage animal rat
2009/6/12
We investigated the effects of 24-h oxygen therapy on focal cerebral ischemia in rats. Under halothane anesthesia, a 3-0 nylon thread was introduced into the neck internal carotid artery to occlude th...
Brain computerized tomography after hyperbaric oxygen therapy for carbon monoxide poisoning
HBO carbon monoxide computerized tomography hyperbaric outcomes
2009/6/9
The role of brain computerized tomography (CT) imaging in predicting clinical outcome was investigated in patients receiving hyperbaric oxygen therapy for serious carbon monoxide (CO) poisoning. From ...