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Background: Epidemiologic evidence regarding niacin, folate, vitamin B-6, and vitamin B-12 intake in relation to cognitive function is limited, especially in midlife.
Background: Epidemiologic evidence regarding niacin, folate, vitamin B-6, and vitamin B-12 intake in relation to cognitive function is limited, especially in midlife.
Background: Public health concerns with regard to both low and high folate status exist in the United States. Recent publications have questioned the utility of self-reported dietary intake data in re...
Background: B vitamins [vitamins B-6, B-9 (folate), and B-12] play important roles in nucleotide biosynthesis and biological methylation reactions, aberrancies of which have all been implicated in car...
Folate and iron status and hemoglobin concentrations are important to maternal and infant health.
Determining folate intake is difficult because existing folate data in food-composition tables are scarce and unreliable.
Current data suggest that physiologic doses of vitamin B-6 have no significant homocysteine-lowering effect. It is possible that an effect of vitamin B-6 was missed in previous trials because of a ...
The serum total homocysteine concentration (tHcy), an indicator of folate status and a possible risk factor for vascular disease, is elevated with impaired renal function and poor vitamin B-12 stat...
Two papers, one reporting serum folate concentrations (1) and one reporting serum homocysteine concentrations (2) in large population samples of US ethnic and racial groups, appeared recently in th...
Many previous investigations of cobalamin and folate status were performed in white populations.
Down syndrome, or trisomy 21, is a complex genetic disease resulting from the presence of 3 copies of chromosome 21. The origin of the extra chromosome is maternal in 95% of cases and is due to the...
One of the major advances in preventing malformations in the past few decades had its origin in the observation by Smithells et al (1) that multivitamin preparations are protective against neural t...
Dried blood spots (DBS) on filter paper have been a successful and economical matrix for neonatal screening.
Premenopausal black women have a greater rate of coronary artery disease (CAD) than do premenopausal white women. Plasma total homocysteine concentrations, a risk factor for CAD, have not been repo...
Mandatory fortification of grain products with folic acid was introduced recently in the United States, a policy expected to result in a mean additional intake of 100 mg/d. One way of predicting th...

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