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It has been shown previously that experimental left varicocele in the rat, results in a bilateral decrease in intratesticular testosterone. In the present work, pituitary responsiveness to GnRH as a...
Chronic renal insufficiency was induced in young adult male rats by a 2-step 5/6 nephrectomy. Four weeks after surgery the rats were anesthetized with ketamine and injected with saline or 1, 5, 10...
Increasing interest in events regulating gonadotropin synthesis and secretion led to the reexamination, by radioimmunoassay (RIA), of the pituitary content of luteinizing hormone (LH) and follicle s...
Men with low serum testosterone levels who do not have elevated serum LH levels are generally thought to have hypothalamic-pituitary dysfunction. To evaluate this concept, seven men with a combinati...
Hormonal studies of pituitary-testicular function in insulin-dependent diabetes mellitus were examined at rest and during moderate exercise to assess whether diabetes per se caused abnormalities of ...
Endogenous testosterone (T), LH and FSH receptors, and in vitro production of cyclic adenosine-3':5'-monophosphate (cAMP), T and some of its steroid precursors were measured in testicular tissue obt...
Eight patients with advanced prostatic carcinoma (ages 59 to 78 years) were treated with a potent gonadotropin-releasing hormone (GnRH) agonist analog (buserelin, Hoechst; 600 micrograms intranasall...
The effect of water restriction on the pituitary-gonadal axis has been studied in adult male rats. Water restriction did not modify FSH, LH and testosterone levels. However, both LH and testosterone...
The roles of testosterone and estradiol in regulating prolactin concentrations were studied in acutely castrated adult male rats receiving subcutaneous Silastic implants of the sex steroids. Testost...
The effect of exogenous follicle stimulating hormone (FSH) on testicular function was studied in twenty 4-month-old Holstein bulls during two seasons (ten in late winter and ten in summer). Five mg ...
Levels of plasma gonadotropins, prolactin (PRL), and testosterone, and the testicular concentration, total content, and affinity of hCG binding sites were measured in male spontaneously hypertensi...
To understand further the effect of prolactin (PRL) on prostatic growth, the present study was undertaken to determine if the augmentation of testosterone (T)-stimulated growth by PRL is mediated ...
Effects of administering low doses of GnRH (30 ng/100 g body weight) at various frequencies on the pituitary-testicular axis were investigated. During a 6-hour treatment period, GnRH was administe...
To characterize the effects of testosterone (T) pretreatment on the response of pituitary LH secretion to exogenous gonadotropin-releasing hormone (GnRH), intact male dogs were injected subcutaneo...
Hyperprolactinemia was induced in adult male golden hamsters by transplantation of four homologous pituitaries under the renal capsules. The resulting elevation of plasma prolactin (PRL) levels wa...

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