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分析颞下颌关节骨关节炎中软骨下骨骨质改建情况,检测Sox9、MMP-13、VEGF的表达并探讨它们对软骨下骨骨质改建的作用机制。方法:在兔关节盘的后外侧制备直径为2.5 mm全层穿孔,micro-CT扫描并计算髁突顶部软骨下骨的BV/TV, BS/BV, Tb.Th, Tb.Sp和Tb.N,HE染色及免疫组织化学方法检测髁突中Sox9、MMP-13、VEGF的表达和定位并进行半定量分析。
Temporal Expression of SOX9 and Type II Collagen in Spheno-Occipital Synchondrosis of Mice after Mechanical Tension Stimuli
Spheno-occipital synchondrosis SOX9 Type II collagen Tensile stress Cartilage
2008/10/29
Objective: To associate the expressions of SOX9 and type II collagen during growth in the synchondrosis with and without tensile stress in order to understand the role of these factors in the growth o...