搜索结果: 1-12 共查到“儿科学 THEIR ROLE”相关记录12条 . 查询时间(0.295 秒)
Role of the Multifunctional DNA Repair and Redox Signaling Protein Ape1/Ref-1 in Cancer and Endothelial Cells: Small-Molecule Inhibition of the Redox Function of Ape1
APE1/Ref-1 redox signaling cancer
2014/12/12
The DNA base excision-repair pathway is responsible for the repair of DNA damage caused by oxidation/alkylation and protects cells against the effects of endogenous and exogenous agents. Removal of th...
Role of Ape1 and Base Excision Repair in the Radiation Response and Heat-radiosensitization of HeLa Cells
radiation hyperthermia DNA repair
2014/12/12
Background: The mechanism by which heat sensitizes mammalian cells to ionizing radiation remains to be elucidated. We determined whether base excision repair (BER) is involved in heat-radiosensitizati...
Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress; Use of APE1 small molecule inhibitors to delineate APE1 functions
base excision repair APE1/Ref-1 oxidative stress
2014/12/12
Oxidative DNA damage has been implicated in a number of central nervous system pathologies. The base excision repair (BER) pathway is one of the most important cellular protection mechanisms that resp...
Prognostic role of Ape/Ref-1 subcellular expression in stage I-III breast carcinomas
DNA repair breast carcinoma immunohistochemistry
2014/12/12
The purpose of the study was to evaluate the prognostic role of the DNA repair protein APE/Ref-1 in breast carcinomas. Immunohistochemical analysis for APE/Ref-1 was performed in a series of 133 conse...
Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells
APE1/Ref-1 cell signaling difference analysis
2014/12/12
Apurinic apyrimidinic endonuclease/redox effector factor 1 (APE1/Ref-1) protects cells from oxidative stress by acting as a central enzyme in base excision repair pathways of DNA lesions and through i...
APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process
APE1/Ref-1 NPM1 rRNA quality control
2014/12/12
APE1/Ref-1 (hereafter, APE1), a DNA repair enzyme and a transcriptional coactivator, is a vital protein in mammals. Its role in controlling cell growth and the molecular mechanisms that fine-tune its ...
Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo: Role of the C-terminal polybasic domain
Rac GTPase NADPH oxidase
2014/12/12
The Rho family GTPase Rac acts as a molecular switch for signal transduction to regulate various cellular functions. Mice deficient in the hematopoietic-specific Rac2 isoform exhibit agonist-specific ...
LEPTIN: A NEW ADYPOCYTE HORMONE AND ITS ROLE IN THE OBESITY
Adipocyte Anthropometric measurement Childhood obesity Regression analysis
2010/1/5
Leptin is a 16-kD protein which is secreted from white adipocytes and, its discovery has generated enormous interest in the regulation of energy balance. Leptin has been implicated in the regulation o...
What Is the Role of Chlamydia pneumonia in Rhinosinusiits of Children?
Rhinosinusitis ELISA test Chlamydia pneumonia
2009/11/24
Chlamydia pneumoniae is a common respiratory pathogen which is often found in our paediatric populations. Many patients with community-acquired pneumonia caused by C. pneumoniae have symptoms suggesti...
The Role of Ultrafiltration Therapy on Blood Pressure of Hypertensive Chronic Hemodialysis Children
Children hemodialysis hypertension hypervolemia ultrafiltration
2009/7/2
Hypervolemia is supposed to be the principal factor in hypertension in chronic hemodialysis adults. In this study, the role of intensive ultrafiltration (UF) treatment to reduce hypertension due to hy...
The role of magnetic resonance imaging in the prediction of the neurodevelopmental outcome of acute bilirubin encephalopathy in newborns
Acute bilirubin encephalopathy hyperbilirubinemia magnetic resonance imaging kernicterus
2010/1/12
Aim: Magnetic resonance imaging (MRI) is widely used in the diagnosis of acute bilirubin encephalopathy, but the relationship between MRI findings and neurodevelopmental outcome in newborns with acute...
A SURVEY OF ANTIBODIES FOR THE EXTRACTABLE NUCLEAR ANTIGENS AND THEIR ROLE IN THE CLINICAL DIAGNOSIS AND PROGNOSIS OF SLE
ANTIGENS THEIR ROLE CLINICAL DIAGNOSIS PROGNOSIS OF SLE
2010/5/7
Fifty-seven patients suffering from systemic lupus erythematosus with different clinical features were studied from various aspects of immunological abnormalities, including anti-nuclear antibodies; a...