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Background: Hepcidin is a key regulator of iron absorption in humans. It is mainly affected by hypoxia and iron stores.
Background: There are different and controversial reports about zinc deficiency in patients with major thalassemia.
Background:: β-Thalassemia is an inherited hemoglobin disorder caused by defective synthesis of ß-globin chains. Hemoglobin (Hb) F induction is a possible therapeutic approach which can partially...
We report a 23-year-old man and three members of his family with Hb J-Iran confirmed by electrophoresis, chain separation by high performance liquid chromatography and sequencing. Alpha thalassemia wa...
Background: Hemoglobin-D (Hb D) is an uncommon structural hemoglobin variant, which is reported to be prevalent in north western India. There are only a few small series, of this entity in the literat...
Beta thalassemia major is a chronic hemolytic anemia because of abnormal hemoglobin synthesis. These patients are at risk for iron overload and tissue intoxication. Heart failure is the most common an...
Background: Ferropenia and consequent iron deficiency anemia (IDA), β-thalassemia, and glucose 6-phosphate dehydrogenase (G6PD) deficiency are three main common hematologic problems in Iran. This stud...
Background: Hepatitis C infection (HCV) is the major co-morbidity in thalassemia patients; however, literature lacks data from many EMRO counties. There is also enormous heterogeneity in the available...
Background: Major Thalassemia is a chronic hemolytic anemia. It is the most common hemoglobinophathy disorder in Khuzestan province. Hypoparathyroidism is one of its endocrinologic complications due t...
The disease of thalassemia major requires mangement by repeated transfusions of packed cell and iron chelators such as deferoxamine. Today, serum ferritin is used for estimation of adequacy of the man...
Objective: Beta major thalassemia is a variant of beta thalassemia syndrome which could be treated with bone marrow transplantation or if not available, regular blood transfusion. In the later group, ...
Alloimmunization can be a significant complication of transfusion therapy in patients with thalassemia and hemoglobinopathies. The aim of this study was to investigate Rh and Kell antigens in patients...
Beta-thalassemia and Sickle cell anemia are serious health problems in the Antalya Province of Turkey as well as World Wide. We aimed to summarize data obtained from the prenatal diagnosis for beta-th...
Objective: In thalassemia major, extramedulary hematopoiesis results in bony deformities such as sever malocclusion in the head and neck, delayed pneumatization of paranasal sinuses and so on. Also, t...
Thalassemia is probably the most common single gene disorder causing a major public health problem in the world. Currently, allogenic hematopoietic stem cell transplantation (HSCT) is the only curativ...

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