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TGF-β Signaling May Play a Role in the Development of Goblet Cell Hyperplasia in a Mouse Model of Allergic Rhinitis
allergic rhinitis epithelial cells Smad TGF-β
2010/11/12
In the mouse model of allergic rhinitis, OVA challenge induced phosphorylation of Smad2 predominantly in epithelial cells in the nasal mucosa. In addition, the administration of an inhibitor of TGF-β ...
Endogenous and Exogenous Thioredoxin 1 Prevents Goblet Cell Hyperplasia in a Chronic Antigen Exposure Asthma Model
airway remodeling asthma goblet cell thioredoxin
2010/11/16
Goblet cell hyperplasia with mucus hypersecretion contribute to increased morbidity and mortality in bronchial asthma. We have reported that thioredoxin 1 (TRX1), a redox (reduction/oxidation)-active ...
Enhanced Goblet Cell Hyperplasia in HDC Knockout Mice with Allergic Airway Inflammation
airway remodeling asthma Gob-5 MUC5AC TNF-α
2010/11/16
The number of eosinophils in BALF increased in both the sensitized wild-type mice and Hdc-/- mice with OVA inhalation. In addition, the numbers of alveolar macrophages and lymphocytes in BALF increase...
