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The first view of the physical mechanism of how a blood clot contracts at the level of individual platelets is giving researchers from the Perelman School of Medicine at the University of Pennsylvania...
The first objective of the meeting is to discuss and critically evaluate new breakthroughs regarding the molecular mechanisms that control excitation-contraction coupling (ECC), how this process is al...
Taping techniques that aim to protect and reduce stress on an injured tissue during rehabilitation are common in sport. Called deloading tape, the mechanism of action is hypothesized to involve effect...
The purpose of this study was to examine central and peripheral factors of fatigability that could explain the differences in fatigability between adults and prepubertal boys after maximal sustained i...
To evaluate the effect of a dentin adhesive on sclerotic dentin, contraction gap width and shear bond strength were measured. Dentin cavity wall was pretreated with an experimental dentin bonding syst...
Cardiac excitation-contraction (E-C) coupling variables were measured in anesthetized cats during helium-oxygen dives to 1000 fsw (305 msw). At constant pacing rates of 190-300/min the delay between o...
Several studies have reported that growth and differentiation of cultured myoblasts can be facilitated by applying appropriate mechanical stimulus. However, the effects of mechanical stimulus on the c...
Erectile function (erection and detumescence) involves the complex interaction of direct neuronal stimulation of corporal smooth muscle, neurohumoral release of specific endothelial contractile an...
The bulbo- and ischio-cavernosus muscles (BCM, ICM) contract in the rigid erection phase, leading to a suprasystolic cavernosal pressure. We investigated the hypothesis that the contraction of caver...
Penile erection results from the balance between relaxation and contractile mechanisms of the corpus cavernosum. Only a few studies suggest a role for endogenous contractile agents such as 5-hydroxy...
Whereas the bulbocavernosus muscle shares its contractile activity with the external anal sphincter (EAS), the response of the ischiocavernosus muscle (ICM) to EAS contraction could not be traced ...
Experiments from this laboratory have demonstrated that vasoconstriction in the cavernosal circulation is mediated, in part, by the RhoA/Rho-kinase calcium-sensitization pathway. When RhoA/Rho-kinase ...
We present a newly developed myograph, an accurate measuring device for muscle contraction, consisting of three elements. Firstly, an element for adjusting the axle of the device and the physiological...
Successful implementation of cardiac cell transplantation for treating damaged myocardium relies on the development of improved injectable biomaterials. A novel biomaterial technology using PEGylated...
Ventricular function has conventionally been characterized using indexes of systolic (contractile) or diastolic (relaxation/stiffness) function. Systolic indexes include maximum elastance or equivalen...

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