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Shp2 deletion in post-migratory neural crest cells results in impaired cardiac sympathetic innervation
Shp2 pERK Bradycardia
2015/5/25
Autonomic innervation of the heart begins in utero and continues during the neonatal phase of life. A balance between the sympathetic and parasympathetic arms of the autonomic nervous system is requir...
SHP2与乳腺癌侵袭转移相关性的研究进展
SHP 2 信号通路 乳腺癌 转移
2014/12/26
含Src同源区2 蛋白质酪氨酸磷酸酶(Src homology 2 domain containing protein tyrosine phosphatases,SHP 2)是一种跨膜型蛋白酪氨酸磷酸酶,通过调节细胞内蛋白质的酪氨酸磷酸化水平,在细胞信号转导通路及控制细胞活性中发挥重要的作用。其活化状态与乳腺癌发生发展过程中的Ras/ERK ,PI 3K/Akt/mTOR等信号通路、激素水平、侵...