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Histologic Evaluation in Patients with Benign Prostatic Hyperplasia Treated with Finasteride and Surgery Alone
5 alpha-reductase inhibitor morphometric analysis Histology of benign prostatic hyperplasia
2009/7/3
In this study, we compared stroma, epithelium, glandular lumen, smooth muscle hyperplasia, inflammation and fibrous components in benign prostatic hyperplasia (BPH) tissue between the group undergone ...
Prevalent decrease of the EGF content in the periurethral zone of BPH tissue induced by treatment with finasteride or flutamide
EGF content periurethral zone BPH flutamide
2009/2/17
The aim of the present investigation is to verify whether treatment with Finasteride or Flutamide influences the regional distribution of testosterone (T), dihydrotestosterone (DHT), and epidermal g...
Effects of a 5 alpha-reductase inhibitor, finasteride, on the developing prostate and testis of a marsupial
Virilization Wolifian duct tammar wallaby androgen dihydrotestosterone
2009/2/17
This study examines the role of dihydrotestosterone in virilization of the developing male tammar. The onset of prostate differentiation in this marsupial species normally occurs around 25 days po...
Effect of finasteride on human testicular steroidogenesis
Alopecia baldness 5cs-reductase 1 7-ketosteroid reductase
2009/2/16
We studied the testicular function and some androgen-mediated events in 22 males (16-30 years of age) with male pattern baldness that was treated with finasteride (10 mg once daily) for 2 years. Pat...
Effect of finasteride on adrenal steroidogenesis in men
5a-Reductase inhibitor androgens dihydrotestosterone
2009/2/12
Finasteride, a 5 alpha-reductase inhibitor, does not bind to the androgen receptor and has no other known hormonal activity. To determine what effect, if any, it has on adrenal steroidogenesis, 10...
Effects of finasteride on the rat ventral prostate
Thymidine incorporation mRNA-prostatein mRNA-TRMP-2
2009/2/11
The objectives of this study were to compare changes in the ventral prostate (VP) of young adult Sprague Dawley rats after 28 days of treatment with finasteride (F), a potent 5 alpha-reductase inhib...
One-year experience in the treatment of benign prostatic hyperplasia with finasteride. The MK-906 (Finasteride) Study Group
Finasteride benign prostatic hyperplasia (BPH)
2009/2/7
Finasteride (MK-906) is a 5 alpha-reductase inhibitor that reduces circulating dihydrotestosterone (DHT) levels without lowering testosterone levels. The goal of this study was to evaluate the e...
Suppression of spermatogenesis with desogestrel and testosterone pellets is not enhanced by addition of finasteride
Suppression of spermatogenesis with desogestrel and testosterone pellets finasteride
2008/12/26
Conversion of testosterone to dihydrotestosterone (DHT) by the action of 5alpha-reductase can amplify androgen action. This may be of particular importance in the presence of low testosterone concentr...
Exogenous Testosterone Alone or With Finasteride Does Not Improve Measurements of Cognition in Healthy Older Men With Low Serum Testosterone
Aging testosterone replacement memory visual spatial function
2008/12/24
Testosterone (T) levels decline as men age, but it is unclear whether this has an effect on cognition. Some studies indicate that lower T levels are associated with memory loss; thus, maintaining a...
Oral Testosterone in Oil：Pharmacokinetic Effects of 5 Reduction by Finasteride or Dutasteride and Food Intake in Men
Androgen hypogonadism metabolism acyline
2008/12/23
Oral administration of 400 mg of testosterone (T) in oil, when combined with the 5 reductase inhibitor dutasteride (D), elevates serum T in medically castrated men to the normal range. In this study...
