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A Comparison of the Effectiveness of Sublingual Losartan,Sublingual Captopril and Sublingual Nifedipine in Hypertensive Urgency
Hypertensive Urgency,Losartan
2009/6/30
The use of sublingual captopril and nifedipine has been indicated in hypertensive emergencies and in patients with essential hypertension, with the assumption that by this route, there would be a fast...
Novel Spectrophotometric Method for the Assay of Captopril in Dosage Forms using 2,6-Dichloroquinone-4-Chlorimide
opril 2,6-dichloroquinone-4-chlorimide (DCQ) spectrophotometry dosage forms
2009/4/29
A simple spectrophotometric method was developed for the determination of captopril (CPL) in pharmaceutical preparations. The method is based on coupling captopril with 2,6-dichloroquinone-4-chlo...
目的建立高效毛细管电泳测定血管紧张素转化酶抑制剂captopril抑制活性的方法。方法用紫外分光光度计确定了马尿酸的特征吸收波长为228 nm。高效毛细管电泳的条件：熔融石英毛细柱，电泳缓冲液为pH 8.3的50 mmol·L-1磷酸缓冲液，进样压力4.8 kPa，进样时间3 s，分离电压20 kV，检测波长228 nm。结果在7 min内使反应物和生成物完全分离，标定了captopril的IC5...
巯甲丙脯酸(captopril)酯类衍生物的合成和药理作用
血管紧张素转换酶抑制剂 抗高血压 巯甲丙脯酸
2010/3/19
巯甲丙脯酸为一新型的血管紧张素转换酶抑制剂,临床用于治疗高血压和充血性心力衰竭。因半衰期短,为了延长药物作用时间和提高药效,本文合成了它的酯和硫醚类衍生物。据初步药理试验结果表明,某些酯类化合物呈现明显的降压活性。