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Cascades of genetic instability resulting from compromised break-induced replication
Comparative Genomic Hybridization Break-induced Replication Copy Number Variations Chromosomal Rearrangements Double-strand Break Repair Half Crossover Homologous Recombination Non-reciprocal Translocation Half crossover instability cascades DNA double-strand break DNA repair Genetic instabilities Array-CGH
2015/5/22
Break-induced replication (BIR) is a mechanism to repair double-strand breaks (DSBs) that possess only a single end that can find homology in the genome. This situation can result from the collapse of...
The Molecular Mechanism of Break Induced Replication
mutagenesis DNA repair recombination replication genomic instability
2015/5/22
DNA double strand break (DSB) is one of the most threatening of all types of DNA damages as it leads to a complete breakage of the chromosome. The cell has evolved several mechanisms to repair DSBs, o...
Genome-destabilizing and Mutagenic Effects of Break-induced Replication in Saccharomyces cerevisiae
genetics DNA mutations saccharomyces cerevisiae
2015/5/22
DNA suffers constant damage, leading to a variety of lesions that require repair. One of the most devastating lesions is a double-strand break (DSB), which results in physical dissociation of two piec...
