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Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation.
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Expression of toll-like receptor 4 and MD-2 gene and protein in Kupffer cells after ischemia-reperfusion in rat liver graft
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英文
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Peng Y,Gong JP,Liu CA,et al
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World J Gastr...
Four-vessel occlusion model,Both vertebral arteries are cauterized,Both common carotid arteries are clamped,Duration of ischemia: 15–30 min.
Postconditioning:A new link in nature’s armor against myocardial ischemia/reperfusion injury
link myocardial ischemia/reperfusion injury
2014/3/31
Area at risk myocardium after reperfusion harvested and stained with Dihydroethidium fluorescence (DHE) to visually assess generation of superoxide anions. A: IR group; B and C: area at risk myocardiu...
Activation of Src tyrosine kinase in microglia in the rat hippocampus following transient forebrain ischemia
Src Phosphorylation Transient forebrain ischemia Microglia
2014/3/31
o better understand the pathophysiological role of Src protein, a non-receptor protein tyrosine kinase of 60 kDa, in the ischemic brain,
we investigated the time course and regional distribution of a...
Induction of Tolerance to Focal Ischemia in Rat Brain: Dissociation Between Cortical Lesioning and Spreading Depression
Rat Brain Cortical Lesioning Spreading Depression
2014/3/31
Cortical application of KCl has previously been
shown to induce tolerance to a subsequent episode of cerebral
ischemia. KCl triggers recurrent episodes of cortical spreading
depression and produces...
Impairment of mitochondrial complex activity associated with ischemia and reperfusion
ischemia reperfusion mitochondrial complex
2014/3/31
It is well known that mitochondrion is the power source of cells and its function is dependent on the activities of respiratory chain complexes. In cardiac myocytes mitochondria are abundant constitut...
A NEUROPROTECTIVE ROLE OF EXTRACELLULAR SIGNAL-REGULATED KINASE IN N-ACETYL- O-METHYLDOPAMINE-TREATED HIPPOCAMPAL NEURONS AFTER EXPOSURE TO IN VITRO AND IN VIVO ISCHEMIA
ERK and CREB phosphorylation neuroprotection N-acetyl- O-methyldopamine selective neu-ronal injury oxygen-glucose deprivation transient forebrain ischemia
2014/3/31
In response to cerebral ischemia, neurons activate
survival/repair pathways in addition to death cascades. Acti-vation of cyclic AMP-response-element-binding protein
(CREB) is linked to neuroprotect...